Evidence map›Paper›PMID 27593185›Full record

Trial reportNeuromuscular disorders : NMD2016

Quantifying disease activity in fatty-infiltrated skeletal muscle by IDEAL-CPMG in Duchenne muscular dystrophy.

Ami Mankodi, Courtney A Bishop, Sungyoung Auh, Rexford D Newbould, Kenneth H Fischbeck, Robert L Janiczek

Open access · hybridAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Neuromuscular disorders : NMD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Magnetic Resonance Imaging Biomarkers of Muscle.Tomography (Ann Arbor, Mich.) · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Quantitative TMuscle & nerve · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ami MankodiNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: Ami.Mankodi@nih.gov.
Courtney A BishopImanova Centre for Imaging Sciences, Hammersmith Hospital, London W12 0NN, UK.
Sungyoung AuhNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Rexford D NewbouldImanova Centre for Imaging Sciences, Hammersmith Hospital, London W12 0NN, UK.
Kenneth H FischbeckNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Robert L JaniczekExperimental Medicine Imaging, Experimental Medicine Unit, GlaxoSmithKline, Middlesex UB11 1BT, UK.
National Institutes of Health · USHammersmith Hospital · GBGlaxoSmithKline (United Kingdom) · GB

Funding

Hereditary Muscle Disease UnitZIANS003131 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MANKODI, AMI · 2012 to 2023
$11.7M
Studies Of Hereditary Neurological Disease: Clinical TrialsZIANS003037 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FISCHBECK, KENNETH · 2009 to 2023
$9.6M
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

The purpose of this study was to explore the use of iterative decomposition of water and fat with echo asymmetry and least-squares estimation Carr-Purcell-Meiboom-Gill (IDEAL-CPMG) to simultaneously measure skeletal muscle apparent fat fraction and water T

Indexed as

Image Interpretation, Computer-AssistedMagnetic Resonance ImagingAdipose TissueAdolescentChildChild, PreschoolDouble-Blind MethodFollow-Up StudiesHumansLeast-Squares AnalysisLinear ModelsMaleMuscle, SkeletalMuscular Dystrophy, DuchenneOligonucleotidesThighOligonucleotidesPRO051Apparent fat fractionDuchenne muscular dystrophyFatty degenerationIDEAL-CPMGMagnetic resonance imagingSkeletal muscleT(2) relaxation timesWater T(2)

Identifiers

PMID27593185
PMCPMC5062949
OpenAlexW2492111900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.