ArticleNeuron2016
Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using ALE coordinate-based meta-analysis to observe resting-state brain abnormalities in subjective tinnitus.Brain imaging and behavior · 2024Pooled it
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice.eNeuro · 2026Article
- Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- Cerebellum Purkinje cell vulnerability in aged rats with memory impairment.The Journal of comparative neurology · 2024Article
- Cerebellar state estimation enables resilient coupling across behavioural domains.Scientific reports · 2024Article
- A system of feed-forward cerebellar circuits that extend and diversify sensory signaling.eLife · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Heterogeneous encoding of temporal stimuli in the cerebellar cortex.Nature communications · 2023Article
- A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.Nature neuroscience · 2023Article
- Locomotion modulates olfactory learning through proprioception in C. elegans.Nature communications · 2023Article
- Variations on the theme: focus on cerebellum and emotional processing.Frontiers in systems neuroscience · 2023Review
- Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon collaterals. Anatomical and optogenetic studies indicate that this non-canonical feedback is region specific: it is most prominent in lobules that regulate eye movement and process vestibular information. Collaterals provide fast, slow, and tonic inhibition to granule cells, and thus allow Purkinje cells to regulate granule cell excitability on multiple timescales. We propose that this feedback mechanism could regulate excitability of the input layer, contribute to sparse coding, and mediate temporal integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.