ArticleEBioMedicine2016
A Magnetoencephalographic (MEG) Study of Gulf War Illness (GWI).
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Oleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.Scientific reports · 2026Trial
- A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects.Molecular neurobiology · 2026Review
- Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents.Scientific reports · 2024Article
- Exposure to Gulf war illness-related chemicals exacerbates alcohol- induced liver damage in rodents.Research square · 2024Article
- Dependence of cognitive ability on synchronous neural interactions determined by magnetoencephalography.Journal of neurophysiology · 2023Article
- MEG neural signature of sexual trauma in women veterans with PTSD.Experimental brain research · 2022Article
- Classification of posttraumatic stress disorder and related outcomes in women veterans using magnetoencephalography.Experimental brain research · 2022Article
- At the Root of 3 "Long" Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome.Neuroscience insights · 2022Review
- Protective Effect of Stem Cells from Toxicity Induced by Gulf War Illness (GWI) Serum in N2A Neuroblastoma Cells.Journal of neurology & neuromedicine · 2021Article
- Modeling Neuroimmune Interactions in Human Subjects and Animal Models to Predict Subtype-Specific Multidrug Treatments for Gulf War Illness.International journal of molecular sciences · 2021Article
- Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions.Life sciences · 2021Article
- Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice.Translational psychiatry · 2021Article
- Association of Lupus Anticoagulant with Brain Atrophy in Gulf War Illness (GWI).Journal of immunological sciences · 2021Article
- Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.Pharmacology & therapeutics · 2021Review
- Classification of Trauma-Related Outcomes in US Veterans Using Magnetoencephalography (MEG).Journal of neurology & neuromedicine · 2021Article
- C-Reactive Protein is Associated with Brain White Matter Anomalies in Gulf War Illness.Journal of neurology & neuromedicine · 2020Article
- Assessing Recovery from Mild Traumatic Brain Injury (Mtbi) using Magnetoencephalography (MEG): An Application of the Synchronous Neural Interactions (SNI) Test.Journal of neurology & neuromedicine · 2020Article
- Human Leukocyte Antigen (HLA) Alleles Prevent Metabolically-Induced Inflammation and Cerebrocortical Thinning in Gulf War Illness.Journal of neurology & neuromedicine · 2020Article
- Gulf War Illness: C-Reactive Protein is Associated with Reduction of the Volume of Hippocampus and Decreased Fractional Anisotropy of the Fornix.Journal of neurology & neuromedicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGulf War Illness (GWI) has affected many Gulf War veterans. It involves several organs, most notably the brain. Neurological-cognitive-mood-related symptoms frequently dominate and are at the root of chronic ill-health and disability in GWI. Here we investigated the neural mechanisms underlying brain dysfunction in GWI in the absence of mental health disorders.
methodsEighty-six veterans completed diagnostic interviews to establish the presence of GWI and assess mental health status. Participants diagnosed with GWI met both Center for Disease Control and Kansas criteria. We studied 46 healthy controls and 40 veterans with GWI without mental illness. They all underwent a resting-state magnetoencephalographic (MEG) scan to assess brain communication based on synchronous neural interactions (SNI; Georgopoulos et al., 2007).
findingsWe found substantial differences in SNI between control and GWI groups centered on the cerebellum and frontal cortex. In addition, using the maxima and minima of SNI per sensor as predictors, we successfully classified 94.2% of the 86 participants (95% sensitivity, 93.5% specificity).
interpretationThese findings document distinct differences in brain function between control and GWI in the absence of mental health comorbidities, differences that are excellent predictors of GWI.
fundingU.S. Department of Veterans Affairs and University of Minnesota.
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Registered trials
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