Evidence map›Paper›PMID 27592330›Full record

ReviewHeart failure reviews2017

Symptom burden in heart failure: assessment, impact on outcomes, and management.

Craig M Alpert, Michael A Smith, Scott L Hummel, Ellen K Hummel

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07280728 (Effectiveness of a Nurse-Led Face-to-Face Educational Intervention on Clinical Stability, Compliance, and Self-Care in Patients With Heart Failure Three Months After Hospital Discharge), which is not on this map. Cited by 130 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 6 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07280728 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of a Nurse-Led Face-to-Face Educational Intervention on Clinical Stability, Compliance, and Self-Care in Patients With Heart Failure Three Months After Hospital Discharge: An Open-Label Randomized Controlled Trial (EDUCATE Study)

TypeinterventionalSponsorAzienda Socio Sanitaria Territoriale di LodiRan2026 to 2029Enrolled118ConditionsChronic Heart FailureArmsNurse-Led Face-to-Face Educational Intervention (Teach-Back Method)
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 6 syntheses or guidelines pooled it, 280 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Health-related quality of life of people with heart failure in low- and middle-income countries: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Pooled it
  4. Spirituality and heart failure: a systematic review.Aging clinical and experimental research · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Feasibility of a Multi-Component Strengths-Building Intervention for Caregivers of Persons With Heart Failure.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Impact of semaglutide on health outcomes and mood in obese heart failure patients: a retrospective analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  17. Article
  18. Article
  19. Clinician-assessed NYHA and EHRA symptom classifications only moderately reflect patient-reported quality of life in heart failure and atrial fibrillation.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Article
  20. Review

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Craig M AlpertDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Michael A SmithDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Scott L HummelDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0924-3135
Ellen K HummelVA Ann Arbor Healthcare System, Ann Arbor, MI, USA. ehummel@med.umich.edu.
VA Ann Arbor Healthcare System · USMichigan Medicine · USUniversity of Michigan · US

Funding

Diet and pathophysiology of heart failure with preserved ejection fractionK23HL109176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUMMEL, SCOTT L · 2011 to 2015
$795k
NHLBI NIH HHS K23 HL109176
6 · The paper itself

Abstract

Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suffer additional symptoms such as pain, depression, gastrointestinal distress, and fatigue. In addition to obvious effects on quality of life, untreated symptoms increase clinical events including emergency department visits, hospitalizations, and long-term mortality in a dose-dependent fashion. Symptom management in patients with HF consists of two key components: comprehensive symptom assessment and sufficient knowledge of available approaches to alleviate the symptoms. Successful treatment addresses not just the physical but also the emotional, social, and spiritual aspects of suffering. Despite a lack of formal experience during cardiovascular training, symptom management in HF can be learned and implemented effectively by cardiology providers. Co-management with palliative medicine specialists can add significant value across the spectrum and throughout the course of HF.

Indexed as

Disease ManagementDisease ProgressionEvidence-Based MedicineGlobal HealthHeart FailureHumansPalliative CarePrevalenceSelf CareSurvival RateTime FactorsHeart failurePalliative careQuality of lifeSupportive careSymptoms

Identifiers

PMID27592330
PMCPMC6042838
OpenAlexW2517280889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.