Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic.

Cason R King, Tanner M Tessier, Joe S Mymryk

Abstract readComment

In one paragraph

Article in Trends in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.2field-weighted citation impact, top 16% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

Post-translational modifications on protein VII are important during the early stages of adenovirus infection.Journal of virology · 2025
Article
Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.Antiviral research · 2021
Review
Drawing on disorder: How viruses use histone mimicry to their advantage.The Journal of experimental medicine · 2018
Review
Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A.mBio · 2018
Review
Mimicry of Cellular A Kinase-Anchoring Proteins Is a Conserved and Critical Function of E1A across Various Human Adenovirus Species.Journal of virology · 2018
Article
Epigenetic Regulation of Viral Biological Processes.Viruses · 2017
Review

4 · The record

Corrections and comments

Comment on
A core viral protein binds host nucleosomes to sequester immune danger signals.2016

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cason R KingDepartment of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.

Tanner M TessierDepartment of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.

Joe S MymrykDepartment of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada; Departments of Oncology and Otolaryngology, University of Western Ontario, London, Ontario, Canada; London Regional Cancer Program and Lawson Health Research Institute, London, Ontario, Canada. Electronic address: jmymryk@uwo.ca.

Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses manipulate cellular chromatin to create a favourable milieu for infection. In several cases, virally-encoded proteins structurally mimic cellular histones to molecularly rewire the host cell. A recent study identified a novel mechanism whereby adenovirus protein VII, a viral histone, binds and manipulates host cell chromatin to suppress inflammatory signalling.

Indexed as

Molecular MimicryAdenoviruses, HumanCell LineChromatinHistonesHMGB1 ProteinHumansInflammationViral ProteinsVirus ReplicationChromatinHistonesHMGB1 ProteinViral ProteinsadenoviruschromatinHMGB1inflammationprotein VIIviral mimicry

Identifiers

PMID27592243

DOI10.1016/j.tim.2016.08.005

OpenAlexW2511688517

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.