ArticleMicrovascular research2017
A novel method for measuring hydraulic conductivity at the human blood-nerve barrier in vitro.
Article in Microvascular research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Hydraulic conductivity of human cancer tissue: A hybrid study.Bioengineering & translational medicine · 2024Article
- Blood-nerve barrier enhances chronic postsurgical pain via the HIF-1α/ aquaporin-1 signaling axis.BMC anesthesiology · 2023Article
- Drug Permeability: From the Blood-Brain Barrier to the Peripheral Nerve Barriers.Advanced therapeutics · 2023Article
- Peristaltic flow in the glymphatic system.Scientific reports · 2020Article
- Biology of the human blood-nerve barrier in health and disease.Experimental neurology · 2020Review
- In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves.Journal of the peripheral nervous system : JPNS · 2019Article
- Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.Frontiers in neuroscience · 2018Review
- GDNF enhances human blood-nerve barrier function in vitro via MAPK signaling pathways.Tissue barriers · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microvascular barrier permeability to water is an essential biophysical property required for the homeostatic maintenance of unique tissue microenvironments. This is of particular importance in peripheral nerves where strict control of ionic concentrations is needed for axonal signal transduction. Previous studies have associated inflammation, trauma, toxin exposure and metabolic disease with increases in water influx and hydrostatic pressure in peripheral nerves with resultant endoneurial edema that may impair axonal function. The regulation of water permeability across endoneurial microvessels that form the blood-nerve barrier (BNB) is poorly understood. Variations exist in apparatus and methods used to measure hydraulic conductivity. The objective of the study was to develop a simplified hydraulic conductivity system using commercially available components to evaluate the BNB. We determined the mean hydraulic conductivity of cultured confluent primary and immortalized human endoneurial endothelial cell layers as 2.00×10
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Registered trials
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