Evidence map›Paper›PMID 27592212›Full record

Observational studySurgery2017

Time-of-day and appendicitis: Impact on management and outcomes.

Frederick Thurston Drake, Neli E Mottey, Anthony A Castelli, Michael G Florence, Morris G Johnson, Scott R Steele, Richard C Thirlby, David R Flum, Writing Group for SCOAP-CERTAIN

Abstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Complicated Appendicitis in a Universal Healthcare System: Do Ethnic Disparities Persist?Health care analysis : HCA : journal of health philosophy and policy · 2026
    Article
  2. Article
  3. Article
  4. Daytime versus Nighttime in Acute Appendicitis.Diagnostics (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. A protocol for non-operative management of uncomplicated appendicitis.The journal of trauma and acute care surgery · 2018
    Article
  9. Observational
  10. Pediatric appendicitis: state of the art review.Pediatric surgery international · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frederick Thurston DrakeDepartment of Surgery, Division of Endocrine Surgery, University of California, San Francisco Medical Center, San Francisco, CA; Department of Surgery, University of Washington Medical Center, Seattle, WA; Department of Surgery, Virginia Mason Medical Center, Seattle, WA; Surgical Outcomes Research Center (SORCE), Department of Surgery, University of Washington, Seattle, WA. Electronic address: Frederick.Drake@ucsf.edu.
Neli E MotteyDepartment of Surgery, University of Washington Medical Center, Seattle, WA; Department of Surgery, Virginia Mason Medical Center, Seattle, WA.
Anthony A CastelliDepartment of Surgery, University of Washington Medical Center, Seattle, WA; Department of Surgery, Virginia Mason Medical Center, Seattle, WA.
Michael G FlorenceDepartment of Surgery, Swedish Medical Center, Seattle, WA.
Morris G JohnsonDepartment of Surgery, Skagit Valley Hospital, Mt. Vernon, WA.
Scott R SteeleDepartment of Surgery, Case Western Reserve University, Cleveland, OH.
Richard C ThirlbyDepartment of Surgery, Virginia Mason Medical Center, Seattle, WA.
David R FlumDepartment of Surgery, University of Washington Medical Center, Seattle, WA; Department of Surgery, Virginia Mason Medical Center, Seattle, WA; Surgical Outcomes Research Center (SORCE), Department of Surgery, University of Washington, Seattle, WA.
Writing Group for SCOAP-CERTAINSurgical Care and Outcomes Assessment Program (SCOAP) and the Comparative Effectiveness Research Translation Network (CERTAIN).

Funding

Renewal: Gastrointestinal Surgery Outcomes Research FellowshipT32DK070555 · NIDDK · UNIVERSITY OF WASHINGTON · PI FLUM, DAVID R · 2010 to 2024
$3.6M
NIDDK NIH HHS T32 DK070555
6 · The paper itself

Abstract

backgroundObservational research has shown that delayed presentation is associated with perforation in appendicitis. Many factors that affect the ability to present for evaluation are influenced by time of day (eg, child care, work, transportation, and office hours of primary care settings). Our objective was to evaluate for an association between care processes or clinical outcomes and presentation time of day.

methodsThe study evaluated a prospective cohort of 7,548 adults undergoing appendectomy at 56 hospitals across Washington State. Relative to presentation time, patient characteristics, time to operation, imaging use, negative appendectomy, and perforation were compared using univariate and multivariate methodologies.

resultsOverall, 63% of patients presented between noon and midnight. More men presented in the morning; however, race, insurance status, comorbid conditions, and white blood cell count did not differ by presentation time. Daytime presenters (6 am to 6 pm) were less likely to undergo imaging (94% vs 98%, P < .05) and had a nearly 50% decrease in median preoperative time (6.0 h vs 8.7 h, P < .001). Perforation significantly differed by time-of-day. Patients who presented during the workday (9 am to 3 pm) had a 30% increase in odds of perforation compared with patients presenting in the early morning/late night (adjusted odds ratio 1.29, 95% confidence interval, 1.05-1.59). Negative appendectomy did not vary by time-of-day.

conclusionMost patients with appendicitis presented in the afternoon/evening. Socioeconomic characteristics did not vary with time-of-presentation. Patients who presented during the workday more often had perforated appendicitis compared with those who presented early morning or late night. Processes of care differed (both time-to-operation and imaging use). Time-of-day is associated with patient outcomes, process of care, and decisions to present for evaluation; this association has implications for the planning of the surgical workforce and efforts directed at quality improvement.

Indexed as

Circadian RhythmEmergency TreatmentAdolescentAdultAppendectomyAppendicitisChildCohort StudiesDisease ManagementEmergency Service, HospitalFollow-Up StudiesHumansMultivariate AnalysisPatient AdmissionPostoperative ComplicationsProspective Studies

Identifiers

PMID27592212
PMCPMC5338748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.