Evidence map›Paper›PMID 27592175›Full record

Trial reportOphthalmology2016

Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects.

Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Siamak Yousefi, Robert N Weinreb

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00221897 recruitingnot on this map

Diagnostic Innovations in Glaucoma Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2030Enrolled3,000ConditionsPrimary Open Angle Glaucoma, Myopia
3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Temporal Optic Disc Microvasculature Dropout in Glaucoma.Investigative ophthalmology & visual science · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min Hee SuhHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California; Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Patricia Isabel C ManalastasHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Akram BelghithHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Adeleh YarmohammadiHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Felipe A MedeirosHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Alberto Diniz-FilhoHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Luke J SaundersHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Siamak YousefiHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California. Electronic address: rweinreb@ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY021818
6 · The paper itself

Abstract

purposeTo investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects.

designCross-sectional, case-control study.

participantsA total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage.

methodsOptical coherence tomography (OCT) angiography-derived circumpapillary vessel density (cpVD) was calculated as the percentage area occupied by vessels in the measured region extracted from the retinal nerve fiber layer (RNFL) in a 750-μm-wide elliptical annulus around the disc. Focal LC defects were detected using swept-source OCT images.

main outcome measuresComparison of global and sectoral (eight 45-degree sectors) cpVDs and circumpapillary RNFL (cpRNFL) thicknesses in eyes with and without LC defects.

resultsAge, global, and sectoral cpRNFL thicknesses, VF mean deviation (MD) and pattern standard deviation, presence of optic disc hemorrhage, and mean ocular perfusion pressure did not differ between patients with and without LC defects (P > 0.05 for all comparisons). Mean cpVDs of eyes with LC defects were significantly lower than in eyes without a defect globally (52.9%±5.6% vs. 56.8%±7.7%; P = 0.013) and in the inferotemporal (IT) (49.5%±10.3% vs. 56.8%±12.2%; P = 0.004), superotemporal (ST) (54.3%±8.8% vs. 58.8%±9.6%; P = 0.030), and inferonasal (IN) (52.4%±9.0% vs. 57.6%±9.1%; P = 0.009) sectors. Eyes with LC defects in the IT sector (n = 33) had significantly lower cpVDs than eyes without a defect in the corresponding IT and IN sectors (P < 0.05 for all). Eyes with LC defects in the ST sector (n = 19) had lower cpVDs in the ST, IT, and IN sectors (P < 0.05 for all).

conclusionsIn eyes with similar severity of glaucoma, OCT-A-measured vessel density was significantly lower in POAG eyes with focal LC defects than in eyes without an LC defect. Moreover, reduction of vessel density was spatially correlated with the location of the LC defect.

Indexed as

Intraocular PressureVisual FieldsAdultAgedAged, 80 and overCase-Control StudiesCross-Sectional StudiesFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiGlaucoma, Open-AngleHumansMaleMiddle AgedNerve Fibers

Identifiers

PMID27592175
PMCPMC5360451

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.