ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2016
Incidence of cancer in adolescent idiopathic scoliosis patients treated 25 years previously.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
104 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Assessing pedicle morphology in pediatric spinal deformity: can magnetic resonance imaging match computed tomography? A systematic review.Spine deformity · 2026Pooled it
- Pooled it
- Adolescent idiopathic scoliosis non-surgical interventions: a systematic review and network meta-analysis of Cobb angle and SRS-22 outcomes.Frontiers in pediatrics · 2026Pooled it
- Long-term cancer risk in historic cohorts of patients with adolescent idiopathic scoliosis: a systematic review.Spine deformity · 2026Pooled it
- Exploring radiation-free scoliosis monitoring: systematic review and meta-analysis of non-ionizing methods.BMC musculoskeletal disorders · 2025Pooled it
- The application of machine learning methods for predicting the progression of adolescent idiopathic scoliosis: a systematic review.Biomedical engineering online · 2024Pooled it
- Is there a skeletal age index that can predict accurate curve progression in adolescent idiopathic scoliosis? A systematic review.Pediatric radiology · 2024Pooled it
- Cancer and mortality risks of patients with scoliosis from radiation exposure: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Pooled it
- Pedicle screw insertion with patient-specific 3D-printed guides based on low-dose CT scan is more accurate than free-hand technique in spine deformity patients: a prospective, randomized clinical trial.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Trial
- Utilization of Magnetic Resonance Imaging-based Synthetic Computed Tomography for Pedicle Screw Navigation in Children: A Feasibility Study.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Evaluation of the effect of Rigo-Chêneau type brace on adolescent idiopathic scoliosis using computer-aided modeling and 3D surface analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- A scoping review on the application of new technology in the screening and diagnosis of adolescent idiopathic scoliosis.Spine deformity · 2026Review
- Posture-dependent assessment of whole-spine curvature with a rotatable cryogen-free 1.5T MRI and automated Cobb angle analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- Cancer risk among women with scoliosis: a nationwide danish register-based study.Spine deformity · 2026Observational
- Radiation-free assessment of the 3D morphology of the adolescent scoliotic spine: a feasibility study using MRI derived quantitative synthetic CT.Spine deformity · 2026Article
- Artificial intelligence-driven 3D surface-topography app for screening and monitoring adolescent scoliosis: early results from a single institution.Spine deformity · 2026Observational
- Improving the reliability of the thumb ossification composite index in patients with scoliosis using EOS imaging with acrylic plates.Spine deformity · 2026Article
- O-arm navigation vs. freehand screw placement in adolescent idiopathic scoliosis: A comparative analysis of screw size and reoperation rates.Acta orthopaedica et traumatologica turcica · 2026Article
- 3D topographic acquisitions to predict spinal curvature in adolescent idiopathic scoliosis : a prospective validation study.Bone & joint open · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the incidence of cancer in a cohort of adolescent idiopathic scoliosis (AIS) patients treated 25 years previously.
methods215 consecutive AIS patients treated between 1983 and 1990 were identified and requested to return for clinical and radiographic examination. The incidence of cancer was determined through chart review and follow-up interviews. Using the original radiographic log file that included patient position, mAs, kV and the total number of X-rays taken, a radiation physicist calculated the total radiation dose during treatment and follow-up adjusted for BMI and sex.
resultsFrom the original cohort of 215 consecutive AIS patients, radiation information was available in 211 of the patients, and medical charts were available in 209 AIS patients. 170 (83 %) of the 205 AIS patients participated in the follow-up study with questionnaires. The calculated mean total radiation exposure was 0.8-1.4 mSV per examination and 2.4-5.6 mSv/year. An average of 16 radiographs were taken during the treatment period. Nine AIS patients developed cancer, mostly breast (3) and endometrial (4). The AIS patients had a relative risk of 4.8 (CI 2.3-5.8, p < 0.000) for developing cancer compared to the normal Danish population.
conclusionsThe overall cancer rate in this AIS cohort was 4.3 % which is five times higher than compared to the age-matched Danish population, and endometrial and breast cancer was most frequent. The radiation dose applied to the patients in this study, is comparable to modern equipment. This is to our knowledge the first study to report increased rates of endometrial cancers in a cohort of AIS patients, and future attention is needed to reduce the radiation dose distributed to the AIS patients both pre-operatively and during surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.