ArticleThe Journal of pediatrics2016
Correlates of Achieving Statin Therapy Goals in Children and Adolescents with Dyslipidemia.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice.The Journal of pediatrics · 2021Trial
- Myopathy in Statin-Treated Children and Adolescents: A Practical Approach.Current atherosclerosis reports · 2024Review
- Hyperlipidemia and Cardiovascular Risk in Children and Adolescents.Biomedicines · 2023Review
- Adherence to lipid-lowering therapy and reaching treatment goals in youth seen in a preventive cardiology clinic.Research in social & administrative pharmacy : RSAP · 2023Article
- Statins in Children, an Update.International journal of molecular sciences · 2023Review
- Dynamic patterns of blood lipids and DNA methylation in response to statin therapy.Clinical epigenetics · 2022Article
- Treatment of Dyslipidaemia in Children.Biomedicines · 2021Review
- Current Approach to the Diagnosis and Treatment of Heterozygote and Homozygous FH Children and Adolescents.Current atherosclerosis reports · 2021Review
- Pediatric Lipid Disorders.Pediatric annals · 2021Article
- Effectiveness and Safety of Statin Therapy in Children: A Real-World Clinical Practice Experience.CJC open · 2020Article
- Statin-Associated Myopathy in a Pediatric Preventive Cardiology Practice.The Journal of pediatrics · 2017Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectiveTo determine the real-world effectiveness of statins and impact of baseline factors on low-density lipoprotein cholesterol (LDL-C) reduction among children and adolescents. STUDY
designWe analyzed data prospectively collected from a quality improvement initiative in the Boston Children's Hospital Preventive Cardiology Program. We included patients ≤21 years of age initiated on statins between September 2010 and March 2014. The primary outcome was first achieving goal LDL-C, defined as <130 mg/dL, or <100 mg/dL with high-level risk factors (eg, diabetes, etc). Cox proportional hazards models were used to assess the impact of baseline clinical and lifestyle factors.
resultsAmong the 1521 pediatric patients evaluated in 3813 clinical encounters over 3.5 years, 97 patients (6.3%) were started on statin therapy and had follow-up data (median age 14 [IQR 7] years, 54% were female, and 24% obese, 62% with at least one lifestyle risk factor). The median baseline LDL-C was 215 (IQR 78) mg/dL, and median follow-up after starting statin was 1 (IQR 1.3) year. The cumulative probability of achieving LDL-C goal within 1 year was 60% (95% CI 47-69). A lower probability of achieving LDL-C goals was associated with male sex (HR 0.5 [95% CI 0.3-0.8]) and higher baseline LDL-C (HR 0.92 [95% CI 0.87-0.98] per 10 mg/dL), but not age, body mass index percentile, lifestyle factors, or family history.
conclusionsThe majority of pediatric patients started on statins reached LDL-C treatment goals within 1 year. Male patients and those with greater baseline LDL-C were less likely to be successful and may require increased support.
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