ArticleThe Journal of pediatrics2016
Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.JAMA pediatrics · 2023Pooled it
- The prevalence and profile of autism in individuals born preterm: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2021Pooled it
- Prevalence of Decreased Sound Tolerance (Hyperacusis) in Individuals With Autism Spectrum Disorder: A Meta-Analysis.Ear and hearingPooled it
- Modified Checklist for Autism in Toddlers in a Neonatal High-Risk Population.JAMA network open · 2026Article
- Reliability and Validity of the Chinese Version of the Rapid Interactive Screening Test for Autism in Toddlers.Journal of autism and developmental disorders · 2026Article
- Integrated follow-up of former extremely preterm infants: how to do it?European journal of pediatrics · 2025Review
- Early developmental trajectory phenotypes for risk stratification of autism spectrum disorder in very preterm infants: a machine learning approach.Molecular autism · 2025Article
- Parallel paths: A narrative review exploring autism and its co-occurring conditions.World journal of clinical pediatrics · 2025Review
- A Direct Comparison of Three Screening Methods for Autism Spectrum Disorder in a High-Likelihood Sibling Population.Journal of autism and developmental disorders · 2025Article
- Implementation of M-Chat for Screening of Early Signs of Autism in the Brazilian Health Care System: A Feasibility Study.Nursing reports (Pavia, Italy) · 2025Article
- Autism screening and diagnostic outcomes among toddlers born preterm.Developmental medicine and child neurology · 2025Article
- Combining developmental and sleep health measures for autism spectrum disorder screening: an ECHO study.Pediatric research · 2025Article
- Brief Report: Psychometric Properties of the Brief Problem Monitor-Parent (BPM-P) 6-18 in a Sample of Children Referred to an Autism Specialty Clinic.Journal of autism and developmental disorders · 2024Article
- Developmental characteristics and accuracy of autism screening among two-year-old toddlers in the ECHO program.Pediatric research · 2024Article
- Association of Growth During Infancy with Neurodevelopment and Obesity in Children Born Very Preterm: The Environmental Influences on Child Health Outcomes Cohort.The Journal of pediatrics · 2024Article
- Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Two-Year Autism Risk Screening and 3-Year Developmental Outcomes in Very Preterm Infants.JAMA pediatrics · 2024Article
- Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions.Journal of autism and developmental disorders · 2024Article
- Neurobehavioral and Medical Correlates of Autism Screening: 2-Year Outcomes for Infants Born Very Preterm.The Journal of pediatrics · 2023Article
- Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
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Abstract
objectiveTo examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth. STUDY
designWe examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT in predicting an ASD diagnosis at age 10 years based on gold standard diagnostic instruments. We then assessed how these predictive parameters were affected by sensorimotor and cognitive impairments, socioeconomic status (SES), and emotional/behavioral dysregulation at age 2 years.
resultsUsing standard criteria, the M-CHAT had a sensitivity of 52%, a specificity of 84%, a PPV of 20%, and an NPV of 96%. False-positive and false-negative rates were high among children with hearing and vision impairments. High false-positive rates also were associated with lower SES, motor and cognitive impairments, and emotional/behavioral dysregulation at age 2 years.
conclusionsAmong extremely preterm children with ASD, almost one-half were not correctly screened by the M-CHAT at age 2 years. Sensorimotor and cognitive impairments, SES, and emotional/behavioral dysregulation contributed significantly to M-CHAT misclassifications. Clinicians are advised to consider these factors when screening very preterm toddlers for ASD.
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