Evidence map›Paper›PMID 27592079›Full record

ReviewTrends in immunology2016

Integrating Inflammasome Signaling in Sexually Transmitted Infections.

Christopher Lupfer, Paras K Anand

Abstract readReview
In one paragraph

Review in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The Interplay betweenMicroorganisms · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher LupferDepartment of Biology, Missouri State University, Springfield, MO 65809, USA.
Paras K AnandInfectious Diseases and Immunity, Imperial College London, London W12 0NN, UK. Electronic address: paras.anand@imperial.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Inflammasomes are cytosolic multiprotein platforms with pivotal roles in infectious diseases. Activation of inflammasomes results in proinflammatory cytokine signaling and pyroptosis. Sexually transmitted infections (STIs) are a major health problem worldwide, yet few studies have probed the impact of inflammasome signaling during these infections. Due to the dearth of appropriate infection models, our current understanding of inflammasomes in STIs is mostly drawn from results obtained in vitro, from distant infection sites, or from related microbial strains that are not sexually transmitted. Understanding how inflammasomes influence the outcome of STIs may lead to the development of novel and effective strategies to control disease and prevent transmission. Here we discuss and highlight the recent progress in this field.

Indexed as

ApoptosisAnimalsCytokinesDisease Models, AnimalHumansInfection ControlInflammasomesInflammation MediatorsSexually Transmitted DiseasesSignal TransductionCytokinesInflammasomesInflammation MediatorsAIM2cancercaspase-1IFI16IL-18IL-1βimmunopathologyinflammasomeinflammationNLRC4NLRP3oncogenicsexually transmitted infectionstumor

Identifiers

PMID27592079
PMCPMC5086000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.