Evidence map›Paper›PMID 27591996›Full record

SynthesisHernia : the journal of hernias and abdominal wall surgery2016

Antibiotic prophylaxis for open mesh repair of groin hernia: systematic review and meta-analysis.

E Erdas, F Medas, G Pisano, A Nicolosi, P G Calò

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Surgical site infection: the "Achilles Heel" of all types of abdominal wall hernia reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2018
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E ErdasChirurgia Generale A, Policlinico Universitario di Monserrato-AOU di Cagliari, Via Mameli, 22, 09124, Cagliari, Italy. erdasernico@libero.it.
F MedasChirurgia Generale A, Policlinico Universitario di Monserrato-AOU di Cagliari, Via Mameli, 22, 09124, Cagliari, Italy.
G PisanoChirurgia Generale A, Policlinico Universitario di Monserrato-AOU di Cagliari, Via Mameli, 22, 09124, Cagliari, Italy.
A NicolosiChirurgia Generale A, Policlinico Universitario di Monserrato-AOU di Cagliari, Via Mameli, 22, 09124, Cagliari, Italy.
P G CalòChirurgia Generale A, Policlinico Universitario di Monserrato-AOU di Cagliari, Via Mameli, 22, 09124, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA meta-analysis was performed to asses whether antibiotic prophylaxis is effective in reducing the incidence of surgical site infection (SSI) after open mesh repair of groin hernia.

methodsA literature search for randomized controlled trials (RCT) evaluating the effectiveness of antibiotic prophylaxis in adult patients undergoing open mesh repair of groin hernia was performed in November 2015. Incidence of overall and deep SSI was considered as primary and secondary outcome measures, respectively. Only studies with a clear definition of SSI and a follow-up of at least 1 month were included. Effect size from each RCT was computed as odds ratio (OR) and 95 % confidence interval (CI) and then data were pooled using a random-effects model.

resultsSixteen RCTs with a total number of 5519 patients were included in the meta-analysis. Considering all the RCTs, antibiotic prophylaxis significantly reduced the overall incidence of SSI from 4.8 % to 3.2 % [OR 0.68, 95 % CI (0.51-0.91)]. However, after removal of two outlier studies, which were identified by evaluating the standardized residual, the result of the meta-analysis became non-significant [OR 0.76, 95 % CI (0.56-1.02)]. The incidence of deep SSI was very low (0-0.7 %) and the effect of antibiotic prophylaxis was not significant [OR 0.80, 95 % CI (0.32-1.99)].

conclusionsThe results of this meta-analysis do not support the routine use of antibiotic prophylaxis for the open mesh repair of groin hernia. In clinical settings with unexpectedly high rates of SSIs, the appropriateness of surgical asepsis should be carefully checked.

Indexed as

Antibiotic ProphylaxisSurgical MeshAnti-Bacterial AgentsGroinHernia, FemoralHernia, InguinalHerniorrhaphyHumansIncidenceRandomized Controlled Trials as TopicSurgical Wound InfectionAnti-Bacterial AgentsAntibiotic prophylaxisInguinal hernia repairSurgical site infection

Identifiers

PMID27591996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.