Evidence map›Paper›PMID 27591916›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016

Older Adults' Perspectives on Clinical Research: A Focus Group and Survey Study.

Eric J Lenze, Alex Ramsey, Patrick J Brown, Charles F Reynolds, Benoit H Mulsant, Helen Lavretsky, Steven P Roose

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Stopping Cognitive Decline in Patients With Late-Life Depression: A New Front in the Fight Against Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Eric J LenzeDepartment of Psychiatry, Washington University, St. Louis, MO, USA. Electronic address: lenzee@wustl.edu.
Alex RamseyDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Patrick J BrownCollege of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
Charles F ReynoldsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Benoit H MulsantCentre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Canada.
Helen LavretskySemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Steven P RooseCollege of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
Washington University in St. Louis · USCentre for Addiction and Mental Health · CAColumbia University · USNew York State Psychiatric InstituteUniversity of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
1/3-Incomplete Response in Late-Life Depression: Getting to RemissionR01MH083660 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 2009 to 2013
$2.7M
2/3-Incomplete Response in Late-Life Depression: Getting to RemissionR01MH083648 · NIMH · WASHINGTON UNIVERSITY · PI LENZE, ERIC J · 2009 to 2013
$2.0M
3/3-Incomplete Response in Late-Life Depression: Getting to RemissionR01MH083643 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI MULSANT, BENOIT H · 2009 to 2013
$1.3M
The Phenomenology and Antidepressant Treatment of Depressed, Frail Older AdultsK23MH099097 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, PATRICK J · 2013 to 2017
$850k
NCATS NIH HHS UL1 TR000448NIMH NIH HHS K23 MH099097NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH083643NIMH NIH HHS R01 MH083648NIMH NIH HHS R01 MH083660NIMH NIH HHS T32 MH020004
6 · The paper itself

Abstract

objectivesClinical trials can benefit from patient perspectives to inform trial design, such as choice of outcome measures. We engaged older adults in focus groups and surveys to get their perspective regarding needs in clinical research. The goal was to inform the development of a new clinical trial of medication strategies for treatment-resistant depression in older adults.

methodsOlder adults with depression participated in focus groups and a subsequent survey in St. Louis and New York. They were queried regarding research design features including outcomes, clinical management, mobile technology and iPad-administered assessments, the collection of DNA, and the receipt of their personal results.

resultsPatients told us: (1) psychological well-being and symptomatic remission are outcomes that matter to them; (2) it is important to measure not only benefits but risks (such as risk of falling) of medications; (3) for pragmatic trials in clinical settings, the research team should provide support to clinicians to ensure that medications are properly prescribed; (4) technology-based assessments are acceptable but there were concerns about data security and burden; (5) DNA testing is very important if it could improve precision care; (6) participants want to receive aggregate findings and their own personal results at the end of the study.

conclusionsPatients gave useful and wide-ranging guidance regarding clinical and comparative effectiveness research in older adults. We discuss these findings with the goal of making the next generation of geriatric studies more impactful and patient-centered.

Indexed as

Attitude to HealthBiomedical ResearchAgedComparative Effectiveness ResearchComputer SecurityDepressive Disorder, Treatment-ResistantFemaleFocus GroupsHumansMajor Depressive DisorderMaleOutcome Assessment, Health CarePragmatic Clinical Trials as TopicQualitative ResearchRisk AssessmentSurveys and Questionnairesantidepressantolder adultspatient perspectivestreatment-resistant depression

Identifiers

PMID27591916
PMCPMC5026966
OpenAlexW2492308421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.