ReviewDiabetologia2016
Combatting type 2 diabetes by turning up the heat.
Review in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Composition and function of the nuchal hump of male Xiphophorus multilineatus.Fish physiology and biochemistry · 2025Article
- Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue.Cell reports. Medicine · 2024Article
- Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice.PloS one · 2024Article
- Dynamic changes of immunocyte subpopulations in thermogenic activation of adipose tissues.Frontiers in immunology · 2024Article
- Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders.Diabetologia · 2023Review
- Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions.Adipocyte · 2022Article
- Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management.The EPMA journal · 2022Article
- Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact.Frontiers in endocrinology · 2022Article
- Measurement of Futile Creatine Cycling Using Respirometry.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model.Alzheimer's research & therapy · 2021Article
- Adipose ABHD6 regulates tolerance to cold and thermogenic programs.JCI insight · 2020Article
- In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes.European journal of nutrition · 2020Article
- SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes.Oxidative medicine and cellular longevity · 2020Article
- A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice.Diabetes · 2019Article
- Intrinsic expression of viperin regulates thermogenesis in adipose tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency.EBioMedicine · 2019Article
- Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.Cell metabolism · 2018Article
- Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro.Lipids in health and disease · 2018Article
- GSK3 is a negative regulator of the thermogenic program in brown adipocytes.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our westernised society, the level of physical activity is low. Interventions that increase energy expenditure are generally associated with an improvement in metabolic health. Exercise and exercise training increase energy metabolism and are considered to be among the best strategies for prevention of type 2 diabetes mellitus. More recently, cold exposure has been suggested to have a therapeutic value in type 2 diabetes. At a cellular level, there is evidence that increasing the turnover of cellular substrates such as fatty acids is associated with preventive effects against lipid-induced insulin resistance. Cellular energy sensors may underlie the effects linking energy turnover with metabolic health effects. Here we review data supporting the hypothesis that increasing energy and substrate turnover has beneficial effects on insulin sensitivity and should be considered a target for the prevention and treatment of type 2 diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.