Evidence map›Paper›PMID 27591786›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Treatment with hydrogen sulfide attenuates sublesional skeletal deterioration following motor complete spinal cord injury in rats.

X Yang, D Hao, H Zhang, B Liu, M Yang, B He

Abstract read
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
  7. H2S Donor and Bone Metabolism.Frontiers in pharmacology · 2021
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

X YangDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Youyi East Road 555, Xi'an, 710054, China.
D HaoDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Youyi East Road 555, Xi'an, 710054, China.
H ZhangDiagnostic Center, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
B LiuDiagnostic Center, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
M YangDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Youyi East Road 555, Xi'an, 710054, China.
B HeDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Youyi East Road 555, Xi'an, 710054, China. hebr_hh2016@hotmail.com.
Xi'an Honghui Hospital · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment with hydrogen sulfide mitigates spinal cord injury-induced sublesional bone loss, possibly through abating oxidative stress, suppressing MMP activity, and activating Wnt/β-catenin signaling.

introductionSpinal cord injury (SCI)-induced sublesional bone loss represents the most severe osteoporosis and is resistant to available treatments to data. The present study was undertaken to explore the therapeutic potential of hydrogen sulfide (H

methodsSCI was generated by surgical transaction of the cord at the T3-T4 levels in rats. Treatment with NaHS was initiated through intraperitoneal injection of 0.1 ml/kg/day of 0.28 mol/l NaHS from 12 h following the surgery and over 14 subsequent days.

resultsH

conclusionTreatment with H

Indexed as

AnimalsBone DensityBone Density Conservation AgentsDisease Models, AnimalDrug EvaluationFemurHydrogen SulfideMaleMatrix Metalloproteinase 9OsteoblastsOsteoclastsOsteoporosisOxidative StressRats, WistarSpinal Cord InjuriesThoracic VertebraeBone Density Conservation AgentsHydrogen SulfideMatrix Metalloproteinase 9Mmp9 protein, ratBone lossHydrogen sulfideOxidative stressSpinal cord injuryWnt/β-catenin signaling

Identifiers

PMID27591786
OpenAlexW2513613305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.