Observational studyClinical & experimental ophthalmology2017
Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency.
Observational study in Clinical & experimental ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Diagnostic criteria for limbal stem cell deficiency before surgical intervention-A systematic literature review and analysis.Survey of ophthalmologyPooled it
- In Vivo Confocal Microscopy Revealed Alteration of Limbal Stem Cells and Sub-Basal Nerve Plexus in Allergic and Dry Eye-Related Ocular Surface Diseases.Translational vision science & technology · 2026Article
- Article
- Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025Review
- Review
- Diagnostic Algorithm for Surgical Management of Limbal Stem Cell Deficiency.Diagnostics (Basel, Switzerland) · 2023Article
- Evaluation of the Effects of Pterygium and Aging on Limbal Structure Using Optical Coherence Tomography.Journal of clinical medicine · 2022Article
- A Review of the Diagnosis and Treatment of Limbal Stem Cell Deficiency.Frontiers in medicine · 2022Review
- Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement.Scientific reports · 2021Observational
- Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy.Investigative ophthalmology & visual science · 2021Article
- Limbal stem cell diseases.Experimental eye research · 2021Review
- Midterm outcomes of penetrating keratoplasty following allogeneic cultivated limbal epithelial transplantation in patients with bilateral limbal stem cell deficiency.International journal of ophthalmology · 2021Article
- Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency.Cornea · 2019Article
- Novel Mutations Associated With Various Types of Corneal Dystrophies in a Han Chinese Population.Frontiers in genetics · 2019Article
- In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography.Translational vision science & technology · 2018Article
- The diagnosis of limbal stem cell deficiency.The ocular surface · 2018Review
- Diagnosis of limbal stem cell deficiency based on corneal epithelial thickness measured on anterior segment optical coherence tomography.Indian journal of ophthalmology · 2017Article
- Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe aims of the study were to investigate limbal epithelial thickness in subjects with limbal stem cell deficiency and to evaluate the correlation between the palisades of Vogt and limbal epithelial thickness.
designCross-sectional observational study.
participantsTwenty-four subjects (39 eyes) with limbal stem cell deficiency and 20 normal controls (20 eyes).
methodsAnterior segment optical coherence tomography and laser scanning confocal microscopy were performed to assess each quadrant of the limbus.
main outcome measuresLimbal epithelial thickness and palisades of Vogt morphology in each quadrant were characterized. The correlation between limbal epithelial thickness and palisades of Vogt was analysed.
resultsThe average limbal epithelial thicknesses in eyes with limbal stem cell deficiency were 19.9%, 23.4%, 13.8% and 13.5% less than normal controls at superior, inferior, nasal and temporal limbus (P = 0.008, 0.006, 0.014 and 0.011, respectively). Limbal epithelial thicknesses within limbal quadrants with palisades of Vogt were similar to those measured in the same quadrants in normal controls, whereas limbal epithelial thicknesses in the superior, inferior, nasal and temporal quadrants without palisades of Vogt were 27.8%, 29.8%, 14.7% and 15.6% less than the limbal epithelial thickness in corresponding regions of normal eyes (superior and inferior: P < 0.001; nasal and temporal: P = 0.005). Limbal epithelial thickness in the nasal and temporal quadrants was significantly less than that in the superior and inferior quadrants, both in normal controls and in limbal stem cell deficiency subjects(P < 0.001 and P = 0.019). Regression analysis showed that limbal epithelial thickness had a significant correlation with the presence of palisades of Vogt in each quadrant (superior, P = 0.002; inferior, P = 0.001; nasal, P = 0.047; temporal, P = 0.030).
conclusionsA significant correlation was found between limbal epithelial thickness and the presence of palisades of Vogt. Limbal epithelial thinning as observed with anterior segment optical coherence tomography is a sign of limbal stem cell deficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.