Evidence map›Paper›PMID 27591323›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

Lyndsey M Muehling, Duy T Mai, William W Kwok, Peter W Heymann, Anna Pomés, Judith A Woodfolk

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Trial
  2. Trial
  3. Trial
  4. The role of virus in nasal inflammation.European journal of medical research · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Human rhinovirus-specific CD8 T cell responses target conserved and unusual epitopes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  14. Article
  15. Human TThe Journal of allergy and clinical immunology · 2020
    Article
  16. Article
  17. Review
  18. [Rhinoviruses].Der Internist · 2019
    Review
  19. Review
  20. Respiratory virus-induced heterologous immunity: Part of the problem or part of the solution?Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lyndsey M MuehlingDepartment of Medicine, University of Virginia Health System, Charlottesville, VA 22908.ORCID 0000-0003-3203-3264
Duy T MaiBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.
Peter W HeymannDepartment of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908; and.
Anna PomésIndoor Biotechnologies Inc., Charlottesville, VA 22903.ORCID 0000-0002-8729-1829
Judith A WoodfolkDepartment of Medicine, University of Virginia Health System, Charlottesville, VA 22908; jaw4m@virginia.edu.
University of Virginia Health System · USVirginia Mason Medical Center · USIndoor Biotechnologies (United States) · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAR01AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLATTS-MILLS, THOMAS A. · 1985 to 2017
$7.1M
An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to aU01AI100799 · NIAID · UNIVERSITY OF VIRGINIA · PI HEYMANN, PETER W, PLATTS-MILLS, THOMAS A. · 2012 to 2015
$5.3M
NIAID NIH HHS R01 AI020565NIAID NIH HHS T32 AI007496NIAID NIH HHS U01 AI100799
6 · The paper itself

Abstract

Rhinovirus (RV) is a major cause of common cold and an important trigger of acute episodes of chronic lung diseases. Antigenic variation across the numerous RV strains results in frequent infections and a lack of durable cross-protection. Because the nature of human CD4

Indexed as

Immunologic MemoryAdolescentAdultCapsid ProteinsCD4-Positive T-LymphocytesEpitope MappingEpitopes, T-LymphocyteHumansMiddle AgedPicornaviridae InfectionsRhinovirusYoung AdultCapsid ProteinsEpitopes, T-Lymphocyte

Identifiers

PMID27591323
PMCPMC5101128
OpenAlexW2509851538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.