Evidence map›Paper›PMID 27591221›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2016

Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes.

Seth W Holwerda, Lauro C Vianna, Robert M Restaino, Kunal Chaudhary, Colin N Young, Paul J Fadel

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Sympathetic transduction to blood pressure in patients with chronic kidney disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Seth W HolwerdaDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa.
Lauro C ViannaFaculty of Physical Education, University of Brasilia, Distrito Federal, Brazil.
Robert M RestainoDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Kunal ChaudharyDepartment of Internal Medicine, University of Missouri, Columbia, Missouri.
Colin N YoungDepartment of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; and.
Paul J FadelDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas paul.fadel@uta.edu.
University of Missouri · USGeorge Washington University · USThe University of Texas at Arlington · USUniversidade de Brasília · BRUniversity of Iowa · US

Funding

Role of Central Neural NFkB and ER Stress in Obesity-induced HypertensionR00HL116776 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI YOUNG, COLIN NEAL · 2015 to 2017
$747k
NHLBI NIH HHS R00 HL116776
6 · The paper itself

Abstract

Despite greater blood pressure reactivity to acute cardiovascular stressors and a higher prevalence of hypertension in type 2 diabetes (T2D) patients, limited information is available regarding arterial baroreflex (ABR) control in T2D. We hypothesized that ABR control of muscle sympathetic nerve activity (MSNA) and heart rate (HR) are attenuated in T2D patients. Seventeen T2D patients (50 ± 2 yr; 31 ± 1 kg/m

Indexed as

AdultArteriesBaroreflexBlood PressureCase-Control StudiesDiabetes Mellitus, Type 2FemaleHeart RateHumansLinear ModelsMaleMiddle AgedMuscle, SkeletalNitroprussideObesityPhenylephrineNitroprussidePhenylephrineVasoconstrictor AgentsVasodilator Agentsarterial blood pressureinsulin resistancemodified oxfordmuscle sympathetic nerve activityobesity

Identifiers

PMID27591221
PMCPMC5243209
OpenAlexW2517322060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.