Evidence map›Paper›PMID 27591218›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2016

Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy.

Thais S Nobre, Ligia M Antunes-Correa, Raphaela V Groehs, Maria Janieire N N Alves, Adriana O Sarmento, Aline V Bacurau, Ursula Urias, Guilherme B Alves, Maria Urbana P B Rondon, Patrícia C Brum and 3 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Article
  7. Cardiac rehabilitation for participants with implantable cardiac devices: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Review
  8. Article
  9. Safety and feasibility of a telemonitoring-guided exercise program in patients receiving cardiac resynchronization therapy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Thais S NobreHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Ligia M Antunes-CorreaHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Raphaela V GroehsHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Maria Janieire N N AlvesHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Adriana O SarmentoHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Aline V BacurauSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Ursula UriasSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Guilherme B AlvesHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Maria Urbana P B RondonSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Patrícia C BrumSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-4750-6506
Martino MartinelliHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Holly R MiddlekauffDepartment of Medicine (Cardiology) and Physiology, Geffen School of Medicine at UCLA, University of California, Los Angeles, California.
Carlos E NegraoHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; cndnegrao@incor.usp.br.
Universidade de São Paulo · BRUniversity of California, Los Angeles · US

Funding

Sympathetic Nerve Activity and the Skeletal Myopathy of Heart FailureR01HL084525 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIDDLEKAUFF, HOLLY R · 2007 to 2010
$1.5M
NHLBI NIH HHS R01 HL084525
6 · The paper itself

Abstract

Heart failure (HF) is characterized by decreased exercise capacity, attributable to neurocirculatory and skeletal muscle factors. Cardiac resynchronization therapy (CRT) and exercise training have each been shown to decrease muscle sympathetic nerve activity (MSNA) and increase exercise capacity in patients with HF. We hypothesized that exercise training in the setting of CRT would further reduce MSNA and vasoconstriction and would increase Ca

Indexed as

Cardiac Resynchronization TherapyExerciseExercise TherapyNeurovascular CouplingCalciumEchocardiographyExercise TestExercise ToleranceFemaleForearmGene ExpressionHeart FailureHumansMaleMiddle AgedMuscle, SkeletalCalciumRNA, MessengerRyanodine Receptor Calcium Release ChannelSodium-Calcium Exchangercardiac resynchronizationexerciseheart failureneurovascular controlskeletal muscle

Identifiers

PMID27591218
PMCPMC6347073
OpenAlexW2547803872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.