Evidence map›Paper›PMID 27591125›Full record

ArticleBiological psychiatry2016

Attention-Deficit/Hyperactivity Disorder Remission Is Linked to Better Neurophysiological Error Detection and Attention-Vigilance Processes.

Giorgia Michelini, Glenn L Kitsune, Celeste H M Cheung, Daniel Brandeis, Tobias Banaschewski, Philip Asherson, Gráinne McLoughlin, Jonna Kuntsi

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In one paragraph

Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Toward Precision Medicine in ADHD.Frontiers in behavioral neuroscience · 2022
    Review
  19. Article
  20. Context Regulation of Mind Wandering in ADHD.Journal of attention disorders · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Giorgia MicheliniMRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom.
Glenn L KitsuneMRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom; Department of Psychological Medicine, London, United Kingdom.
Celeste H M CheungDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychological Sciences, Centre for Brain and Cognitive Development, Birkbeck, University of London, London, United Kingdom.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy , Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, Zurich, Switzerland; Center for Integrative Human Physiology, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy , Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Philip AshersonMRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom.
Gráinne McLoughlinMRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom.
Jonna KuntsiMRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom. Electronic address: jonna.kuntsi@kcl.ac.uk.

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Medical Research Council G0300189Medical Research Council G9817803Medical Research Council MR/N013182/1NIMH NIH HHS R01 MH062873
6 · The paper itself

Abstract

backgroundThe processes underlying persistence and remission of attention-deficit/hyperactivity disorder (ADHD) are poorly understood. We examined whether cognitive and neurophysiological impairments on a performance-monitoring task distinguish between ADHD persisters and remitters.

methodsOn average 6 years after initial assessment, 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched control participants were compared on cognitive-performance measures and event-related potentials of conflict monitoring (N2) and error processing (error-related negativity and positivity) from an arrow flanker task with low-conflict and high-conflict conditions. ADHD outcome was examined with parent-reported symptoms and functional impairment measures using a categorical (DSM-IV) and a dimensional approach.

resultsADHD persisters were impaired compared with controls on all cognitive-performance and event-related potential measures (all p < .05). ADHD remitters differed from persisters and were indistinguishable from control participants on the number of congruent (low-conflict) errors, reaction time variability, error-related negativity, and error-related positivity (all p ≤ .05). Remitters did not differ significantly from the other groups on incongruent (high-conflict) errors, mean reaction time, and N2. In dimensional analyses on all participants with childhood ADHD, ADHD symptoms and functional impairment at follow-up were significantly correlated with congruent errors, reaction time variability, and error-related positivity (r = .19-.23, p ≤ .05).

conclusionsCognitive and neurophysiological measures of attention-vigilance and error detection distinguished ADHD remitters from persisters. These results extend our previous findings with other tasks and indicate that such measures are markers of remission and candidates for the development of nonpharmacological interventions.

Indexed as

Disease ProgressionAdolescentAdultAttention Deficit Disorder with HyperactivityCognitive DysfunctionElectroencephalographyEvoked PotentialsExecutive FunctionFemaleFollow-Up StudiesHumansMalePsychomotor PerformanceRemission InductionYoung AdultADHDCognitive impairmentsEEGEvent-related potentialsPersistenceRemission

Identifiers

PMID27591125
PMCPMC5120985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.