ArticleTherapeutic advances in respiratory disease2016
Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD.
Article in Therapeutic advances in respiratory disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The prevalence and related factors of fatigue in patients with COPD: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Using step counters to promote physical activity and exercise capacity in patients with chronic obstructive pulmonary disease: a meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Effect of progressive muscle relaxation as an add-on to pulmonary telerehabilitation in discharged patients with COVID-19: A randomised controlled trial.Complementary therapies in clinical practice · 2023Trial
- Fatigue in COPD: a Longitudinal, Multidimensional Perspective.International journal of behavioral medicine · 2026Article
- Mental vulnerability, family dysfunction, and digital exposure: Overlooked burdens in populations with noncommunicable chronic diseases.World journal of psychiatry · 2025Article
- Identifying and developing EQ-5D-5L bolt-on items for Chinese chronic obstructive pulmonary disease patients.Health and quality of life outcomes · 2025Article
- Associated factors of fatigue in patients with COPD: results from the FAntasTIGUE study.ERJ open research · 2025Article
- Effectiveness of Combined Pulmonary Rehabilitation and Progressive Muscle Relaxation in Treating Long-Term COVID-19 Symptoms: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Establishing the Validity of Using the COPD Assessment Test to Screen for Fatigue in People With Chronic Obstructive Pulmonary Disease Referred to Pulmonary Rehabilitation.Physical therapy · 2023Article
- Flourishing despite Chronic Obstructive Pulmonary Disease (COPD): Findings from a Nationally Representative Survey of Canadians Aged 50 and Older.International journal of environmental research and public health · 2022Article
- Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study.Scientific reports · 2021Article
- Frailty, a Dimension of Impaired Functional Status in Advanced COPD: Utility and Clinical Applicability.Medicina (Kaunas, Lithuania) · 2021Review
- Fatigue in cancer patients: comparison with the general population and prognostic factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Severe Fatigue is Highly Prevalent in Patients with IPF or Sarcoidosis.Journal of clinical medicine · 2020Article
- Statistical analysis plan for "A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using a tobacco heating product on health effect indicators in healthy subjects".Contemporary clinical trials communications · 2020Article
- Evaluation of sleep quality and daytime somnolence in patients with chronic obstructive pulmonary disease in pulmonary rehabilitation.BMC pulmonary medicine · 2020Article
- The Impact of Twice-Daily Indacaterol/Glycopyrrolate on the Components of Health-Related Quality of Life and Dyspnea in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Article
- Pulmonary Rehabilitation Reduces Subjective Fatigue in COPD: A Responder Analysis.Journal of clinical medicine · 2019Article
- Fatigue in the general population: German normative values of the EORTC QLQ-FA12.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Physical frailty characteristics have a differential impact on symptoms as measured by the CAT score: an observational study.Health and quality of life outcomes · 2018Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the influence of selected physiological, psychological and situational factors on experience of fatigue, and functional limitations due to fatigue in patients with stable chronic obstructive pulmonary disease (COPD).
methodsIn total 101 patients with COPD and 34 control patients were assessed for experience of fatigue, functional limitation due to fatigue (Fatigue Impact Scale), physiological [lung function, 6-minute walk distance (6MWD), body mass index (BMI), dyspnoea, interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hs-CRP), surfactant protein D], psychological (anxiety, depression, insomnia), situational variables (age, sex, smoking, living alone, education), and quality of life.
resultsFatigue was more common in patients with COPD than in control patients (72% versus 56%, p < 0.001). Patients with COPD and fatigue had lower lung function, shorter 6MWD, more dyspnoea, anxiety and depressive symptoms, and worse health status compared with patients without fatigue (all p < 0.01). No differences were found for markers of systemic inflammation. In logistic regression, experience of fatigue was associated with depression [odds ratio (OR) 1.69, 95% confidence interval (CI) 1.28-2.25) and insomnia (OR 1.75, 95% CI 1.19-2.54). In linear regression models, depression, surfactant protein D and dyspnoea explained 35% (R(2)) of the variation in physical impact of fatigue. Current smoking and depression explained 33% (R(2)) of the cognitive impact of fatigue. Depression and surfactant protein D explained 48% (R(2)) of the psychosocial impact of fatigue.
conclusionsExperiences of fatigue and functional limitation due to fatigue seem to be related mainly to psychological but also to physiological influencing factors, with depressive symptoms, insomnia problems and dyspnoea as the most prominent factors. Systemic inflammation was not associated with perception of fatigue but surfactant protein D was connected to some dimensions of the impact of fatigue.
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