ReviewBiochimica et biophysica acta. Gene regulatory mechanisms2017
Putting DNA methylation in context: from genomes to gene expression in plants.
Review in Biochimica et biophysica acta. Gene regulatory mechanisms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 161 citations in OpenAlex.
- Repeated drought induces a reproducible DNA methylation response associated with gene expression inbioRxiv : the preprint server for biology · 2026Article
- Convergence and divergence of DNA methylation and gene expression patterns in neopolyploid Arabidopsis kamchatica.Nature communications · 2026Article
- Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies.The New phytologist · 2026Review
- Reversibility of sex changes in the plant kingdom: more important than we thought?Biological reviews of the Cambridge Philosophical Society · 2025Review
- Phased epigenomics and methylation inheritance in a historical Vitis vinifera hybrid.Genome biology · 2025Article
- DMRU: generative deep learning to unravel condition-specific cytosine methylation in plants.Briefings in bioinformatics · 2025Article
- Epigenetics in forest trees- key driver to phenotypic plasticity and adaptation under stress.Functional & integrative genomics · 2025Review
- Epigenetic responses of trees to environmental stress in the context of climate change.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis.Nature plants · 2025Article
- Uncovering DNA methylation landscapes to decipher evolutionary footprints of phenotypic diversity in chickpea.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- DNA methylation signatures of duplicate gene evolution in angiosperms.Plant physiology · 2023Article
- Review
- DDM1-Mediated TE Silencing in Plants.Plants (Basel, Switzerland) · 2023Review
- Epitype-inducing temperatures drive DNA methylation changes during somatic embryogenesis in the long-lived gymnosperm Norway spruce.Frontiers in plant science · 2023Article
- Current status of the cryopreservation of embryogenic material of woody species.Frontiers in plant science · 2023Review
- DNA methylation in clonal duckweed (Lemna minor L.) lineages reflects current and historical environmental exposures.Molecular ecology · 2023Article
- Parental methylation mediates how progeny respond to environments of parents and of progeny themselves.Annals of botany · 2022Article
- Epigenetic Mechanisms of Tree Responses to Climatic Changes.International journal of molecular sciences · 2022Review
- Integration of DNA Methylation and Transcriptome Data Improves Complex Trait Prediction inPlants (Basel, Switzerland) · 2022Article
- The Methylation Inhibitor 5-Aza-2'-Deoxycytidine Induces Genome-Wide Hypomethylation in Rice.Rice (New York, N.Y.) · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Plant DNA methylation is its own language, interpreted by the cell to maintain silencing of transposons, facilitate chromatin structure, and to ensure proper expression of some genes. Just as in any language, context is important. Rather than being a simple "on-off switch", DNA methylation has a range of "meanings" dependent upon the underlying sequence and its location in the genome. Differences in the sequence context of individual sites are established, maintained, and interpreted by differing molecular pathways. Varying patterns of methylation within genes and surrounding sequences are associated with a continuous range of expression differences, from silencing to constitutive expression. These often-subtle differences have been pieced together from years of effort, but have taken off with the advent of methods for assessing methylation across entire genomes. Recognizing these patterns and identifying underlying causes is essential for understanding the function of DNA methylation and its systems-wide contribution to a range of processes in plant genomes. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.