Evidence map›Paper›PMID 27590749›Full record

ArticleAllergy2017

Nasal and sinus symptoms and chronic rhinosinusitis in a population-based sample.

A G Hirsch, W F Stewart, A S Sundaresan, A J Young, T L Kennedy, J Scott Greene, W Feng, B K Tan, R P Schleimer, R C Kern and 2 more

Open access · greenAbstract read
In one paragraph

Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 4 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 4 syntheses or guidelines pooled it, 280 citations in OpenAlex.

  1. The percentage of controlled chronic rhinosinusitis after treatment: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
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  9. Observational
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  14. Evaluating the efficacy and readability of advanced large language models in responding to patients' frequently asked questions about chronic rhinosinusitis: a comparative analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  15. Cannabis Use and Risk of Chronic Rhinosinusitis and Sinus Surgery.Laryngoscope investigative otolaryngology · 2025
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  16. Article
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  18. [Initial exploration of non-invasive diagnosis of eosinophilic chronic rhinosinusitis with nasal polyps via nasal brush sampling].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  19. Article
  20. Advancements and future directions in chronic rhinosinusitis: understanding inflammatory mechanisms (2000-2023).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Review

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

A G HirschDepartment of Epidemiology and Health Services Research, Geisinger Health System, Danville, PA, USA.
W F StewartResearch Development and Dissemination, Sutter Health, San Francisco, CA, USA.
A S SundaresanDepartment of Epidemiology and Health Services Research, Geisinger Health System, Danville, PA, USA.
A J YoungDepartment of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
T L KennedyDepartment of Otolaryngology/Head and Neck/Facial Plastic Surgery, Geisinger Health System, Danville, PA, USA.
J Scott GreeneDepartment of Otolaryngology/Head and Neck/Facial Plastic Surgery, Geisinger Health System, Danville, PA, USA.
W FengDepartment of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
B K TanDepartment of Otolaryngology Head and Neck Surgery Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
R P SchleimerDepartment of Otolaryngology Head and Neck Surgery Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
R C KernDepartment of Otolaryngology Head and Neck Surgery Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
A LidderUniversity of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
B S SchwartzDepartment of Epidemiology and Health Services Research, Geisinger Health System, Danville, PA, USA.
Geisinger Health System · USNorthwestern University · USJohns Hopkins University · USSutter Health · USUniversity of Rochester Medical Center · US

Funding

Systems Genetics Approach to Gene Discovery in Chronic RhinosinusitisU19AI106683 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KERN, ROBERT C · 2014 to 2017
$7.9M
Glucocorticosteroid Action In Inflammatory DiseaseR37HL068546 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2009 to 2018
$3.5M
Systems Genetics Approach to Gene Discovery in Chronic RhinosinusitisP01AI106683 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2013 to 2013
$1.7M
NHLBI NIH HHS R37 HL068546NIAID NIH HHS P01 AI106683NIAID NIH HHS U19 AI106683
6 · The paper itself

Abstract

backgroundThe objective of this study was to describe the first US-based study to use the European Position Paper on Rhinosinusitis (EPOS) criteria to study the prevalence of chronic rhinosinusitis (CRS) in a general-population sample.

methodsA CRS symptom questionnaire was mailed to 23 700 primary care patients from Geisinger Clinic, a health system serving 45 counties in Pennsylvania. CRS cases were categorized into four unique subgroups based on EPOS symptoms: obstruction and discharge with no smell loss or pain/pressure; smell loss without pain/pressure; facial pain and/or pressure without smell loss; and both smell loss and pain/pressure. All cases were required to have nasal obstruction or discharge. Logistic regression was used to evaluate potential factors associated with CRS subgroups.

resultsWe found that 11.9% of patients met criteria for CRS. Prevalence peaked at 15.9% between ages 50 and 59 years and then dropped to 6.8% after age 69. The odds of CRS was higher among patients who were white, younger, smokers, had a history of Medical Assistance, and had other diseases. When CRS subgroups were modeled separately, these associations were no longer significant for some CRS subgroups. Comorbid diseases were most strongly associated with CRS cases who reported smell loss and facial pain and/or pressure and had the weakest associations with CRS cases who did not report these symptoms.

conclusionsCRS is a highly prevalent and heterogeneous condition. Differences in risk factors and health outcomes across symptom subgroups may be indicative of differences in etiology that have implications for disease management.

Indexed as

Population SurveillanceSymptom AssessmentAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedOdds RatioPennsylvaniaPhenotypePrevalenceRhinitisSinusitisSocioeconomic Factorschronic rhinosinusitisepidemiology

Identifiers

PMID27590749
PMCPMC5497579
OpenAlexW2515977513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.