Evidence map›Paper›PMID 27590721›Full record

ReviewBrain research2017

Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?

David J Piekarski, Carolyn M Johnson, Josiah R Boivin, A Wren Thomas, Wan Chen Lin, Kristen Delevich, Ezequiel M Galarce, Linda Wilbrecht

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 4 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.

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  13. Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David J PiekarskiDepartment of Psychology, University of California, Berkeley, Berkeley CA 94720, USA.
Carolyn M JohnsonDepartment of Psychology, University of California, Berkeley, Berkeley CA 94720, USA.
Josiah R BoivinNeuroscience Graduate Program, University of California, San Francisco, San Francisco CA 94158, USA.
A Wren ThomasHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA.
Wan Chen LinDepartment of Psychology, University of California, Berkeley, Berkeley CA 94720, USA.
Kristen DelevichDepartment of Psychology, University of California, Berkeley, Berkeley CA 94720, USA.
Ezequiel M GalarceSchool of Public Health, University of California, Berkeley, Berkeley CA 94720, USA.
Linda WilbrechtDepartment of Psychology, University of California, Berkeley, Berkeley CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA. Electronic address: wilbrecht@berkeley.edu.
University of California, Berkeley · USUniversity of California, San Francisco · US

Funding

Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
Effects of adolescent cocaine on frontal spine turnover, synapses, and behaviorR01DA029150 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILBRECHT, LINDA E · 2010 to 2016
$2.5M
Longitudinal Imaging of Frontal Cortex Afferents in a Mouse Model of AnxietyR01MH087542 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILBRECHT, LINDA E · 2009 to 2013
$2.0M
Corticostriatal circuits in behavioral flexibilityF32MH110184 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI DELEVICH, KRISTEN MARIE · 2016 to 2018
$171k
Does acceleration of puberty accelerate prefrontal cortex development in mice?F32MH110107 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI PIEKARSKI, DAVID JOHN · 2016 to 2017
$119k
NIDA NIH HHS R01 DA029150NIMH NIH HHS F32 MH110107NIMH NIH HHS F32 MH110184NIMH NIH HHS R01 MH087542NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

Postnatal brain development is studded with sensitive periods during which experience dependent plasticity is enhanced. This enables rapid learning from environmental inputs and reorganization of cortical circuits that matches behavior with environmental contingencies. Significant headway has been achieved in characterizing and understanding sensitive period biology in primary sensory cortices, but relatively little is known about sensitive period biology in associative neocortex. One possible mediator is the onset of puberty, which marks the transition to adolescence, when animals shift their behavior toward gaining independence and exploring their social world. Puberty onset correlates with reduced behavioral plasticity in some domains and enhanced plasticity in others, and therefore may drive the transition from juvenile to adolescent brain function. Pubertal onset is also occurring earlier in developed nations, particularly in unserved populations, and earlier puberty is associated with vulnerability for substance use, depression and anxiety. In the present article we review the evidence that supports a causal role for puberty in developmental changes in the function and neurobiology of the associative neocortex. We also propose a model for how pubertal hormones may regulate sensitive period plasticity in associative neocortex. We conclude that the evidence suggests puberty onset may play a causal role in some aspects of associative neocortical development, but that further research that manipulates puberty and measures gonadal hormones is required. We argue that further work of this kind is urgently needed to determine how earlier puberty may negatively impact human health and learning potential. This article is part of a Special Issue entitled SI: Adolescent plasticity.

Indexed as

AnimalsHumansNeocortexNeuronal PlasticityPubertySexual MaturationExecutive functionFrontal cortexInhibitionPubertySensitive periodSteroid hormones

Identifiers

PMID27590721
PMCPMC5283387
OpenAlexW2510195464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.