Evidence map›Paper›PMID 27590629›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes.

Mark A Espeland, Kasia Lipska, Michael E Miller, Julia Rushing, Ronald A Cohen, Joseph Verghese, Mary M McDermott, Abby C King, Elsa S Strotmeyer, Steven N Blair and 5 more

Abstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  17. Effectiveness of A Pilates Training Program on Cognitive and Functional Abilities in Postmenopausal Women.International journal of environmental research and public health · 2020
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mark A EspelandWake Forest School of Medicine.
Kasia LipskaYale School of Medicine.
Michael E MillerWake Forest School of Medicine.
Julia RushingWake Forest School of Medicine.
Ronald A CohenUniversity of Florida.
Joseph VergheseAlbert Einstein College of Medicine.
Mary M McDermottNorthwestern University Fienberg School of Medicine.
Abby C KingStanford University School of Medicine.
Elsa S StrotmeyerUniversity of Pittsburgh.
Steven N BlairUniversity of South Carolina.
Marco PahorUniversity of Florida.
Kieran ReidTufts University.
Jamehl DemonsWake Forest School of Medicine.
Stephen B KritchevskyWake Forest School of Medicine.
LIFE Study Investigators

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Karyn A Esser, Todd Manini · 2007 to 2026
$22.8M
WISE II - Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain FunctionR01DK099334 · NIDDK · UNIVERSITY OF FLORIDA · PI RONALD A COHEN, Eric Porges · 2014 to 2026
$4.6M
Predicting Severe Hypoglycemia among Older Adults with DiabetesK23AG048359 · NIA · YALE UNIVERSITY · PI LIPSKA, KASIA JOANNA · 2014 to 2018
$778k
NIA NIH HHS K23 AG048359NIA NIH HHS L30 AG045923NIA NIH HHS P30 AG028740NIDDK NIH HHS R01 DK099334
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.

methodsThe Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.

resultsAt 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95% confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.

conclusionsPhysical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.

Indexed as

CognitionExerciseSedentary BehaviorWalking SpeedAgedAged, 80 and overDiabetes Mellitus, Type 2FemaleGaitHumansMaleNeuropsychological TestsSingle-Blind MethodBehavioral interventionClinical trialsType 2 diabetes

Identifiers

PMID27590629
PMCPMC6075086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.