ArticleCancer prevention research (Philadelphia, Pa.)2016
Height and Body Size in Childhood, Adolescence, and Young Adulthood and Breast Cancer Risk According to Molecular Subtype in the Nurses' Health Studies.
Article in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 39 citations in OpenAlex.
- Early-Life Exposures and Risk of Multiple Myeloma: A Population-Based Case-Control Study in Australia.International journal of cancer · 2026Article
- Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts.Breast cancer research : BCR · 2025Article
- Is early-life obesity associated with kidney cancer in adulthood?-insights from genetic studies.Translational andrology and urology · 2025Article
- Current trends in breast cancer genetics, risk factors, and screening strategies.Journal of biological methods · 2025Review
- Height and breast cancer risk in premenopausal Korean women aged under 40 years of age.British journal of cancer · 2024Article
- The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.Cancers · 2024Article
- Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study.American journal of epidemiology · 2022Article
- Article
- Early-Life Body Adiposity and the Breast Tumor Transcriptome.Journal of the National Cancer Institute · 2021Article
- Cancer Progress and Priorities: Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer.Cancer prevention research (Philadelphia, Pa.) · 2021Observational
- Body Habitus Across the Lifespan and Risk of Pituitary Adenoma.The Journal of clinical endocrinology and metabolism · 2021Article
- Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations.NPJ breast cancer · 2021Article
- Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen School Health Records Register.International journal of obesity (2005) · 2020Review
- In utero DDT exposure and breast density before age 50.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Early-Life and Adult Anthropometrics in Relation to Mammographic Image Intensity Variation in the Nurses' Health Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women.Breast (Edinburgh, Scotland) · 2020Article
- Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics.Scientifica · 2020Review
- Metabolic Health, Insulin, and Breast Cancer: Why Oncologists Should Care About Insulin.Frontiers in endocrinology · 2020Review
- Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.Cancer causes & control : CCC · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Height and body size in childhood and young adulthood have been consistently associated with breast cancer risk; whether associations differ across molecular subtypes is unclear. In a pooled analysis of the Nurses' Health Studies, we prospectively examined the association of four exposures: height, body mass index (BMI) at the age of 18 years, childhood and adolescent somatotypes, with breast cancer risk according to molecular subtypes defined by immunohistochemical markers. We used multivariable-adjusted Cox proportional hazards regression to estimate HRs and 95% confidence intervals (CI). We identified 2,983 luminal A, 1,281 luminal B, 318 HER2-enriched, 408 basal-like, and 128 unclassified tumors. Height was positively associated with all subtypes (Pheterogeneity = 0.78). BMI at the age of 18 (Pheterogeneity = 0.001), childhood (Pheterogeneity = 0.51), and adolescent somatotype (Pheterogeneity = 0.046) were inversely associated, but with differences in magnitude of association. BMI at the age of 18 of ≥25 kg/m(2) (compared with 20-21.9 kg/m(2)) was associated with a 52% decreased risk of HER2-enriched (HR, 0.48; 95% CI, 0.26-0.91; Ptrend < 0.0001) and 39% reduced risk of basal-like tumors (HR, 0.61; 95% CI, 0.36-1.02; Ptrend = 0.008). Compared with the lowest category, women in the highest adolescent body size category were 71% less likely to develop HER2-enriched (HR, 0.29; 95% CI, 0.10-0.85; Ptrend = 0.0005) and 60% less likely to develop basal-like (HR, 0.40; 95% CI, 0.17-0.95; Ptrend = 0.0008). Height was positively associated with risk of all breast cancer molecular subtypes. BMI at 18 years and childhood and adolescent were inversely associated with risk of most breast cancer molecular subtypes with somewhat stronger associations with HER2-enriched and basal-like subtypes. Cancer Prev Res; 9(9); 732-8. ©2016 AACR.
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