ArticleJournal of gastroenterology2017
Early gastric cancer with a mixed-type Lauren classification is more aggressive and exhibits greater lymph node metastasis.
Article in Journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between histological mixed-type early gastric cancer and lymph node metastasis: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Pattern of lymph node metastases in gastric cancer: a side-study of the multicenter LOGICA-trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Trial
- Does total omentectomy increase survival in laparoscopic gastric cancer surgery? A retrospective study.BMC surgery · 2026Article
- Blood ctDNA-specific markers predict the risk of peritoneal metastasis for advanced gastric cancer.Discover oncology · 2025Article
- Nomogram for pre-procedural prediction of lymph node metastasis in patients with submucosal early gastric cancer.Surgical endoscopy · 2025Article
- Preoperative prediction of the Lauren classification in gastric cancer using automated nnU-Net and radiomics: a multicenter study.Insights into imaging · 2025Article
- Management Strategy of Non-curative ESD in Gastric Cancer: Curative Criteria, and the Critical Building Block for Determining Beyond It.Journal of gastric cancer · 2025Review
- Machine learning models for prediction of lymph node metastasis in patients with T1b gastric cancer.American journal of cancer research · 2024Article
- Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Locally Advanced Gastric Cancer.Cancer management and research · 2024Article
- The percentages of signet-ring cells (SRCs) affects the prognosis after radical gastrectomy for advanced gastric cancer.Langenbeck's archives of surgery · 2023Article
- Deep learning-based subtyping of gastric cancer histology predicts clinical outcome: a multi-institutional retrospective study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Epstein-Barr virus detection in endoscopic submucosal dissection-proven early gastric cancer with mixed-type histology.Cancer reports (Hoboken, N.J.) · 2023Article
- Clinicopathological characteristics of early gastric cancer with different level of undifferentiated component and nomogram to predict lymph node metastasis.Frontiers in surgery · 2023Article
- A nomogram based on platelet-to-lymphocyte ratio for predicting lymph node metastasis in patients with early gastric cancer.Frontiers in oncology · 2023Article
- A 9‑gene expression signature to predict stage development in resectable stomach adenocarcinoma.BMC gastroenterology · 2022Article
- Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: Updated review of definition, classification and therapeutic management.World journal of gastrointestinal oncology · 2022Review
- Prognostic value of molecular cytology by one-step nucleic acid amplification (OSNA) assay of peritoneal washings in advanced gastric cancer patients.Scientific reports · 2022Article
- Molecular pathogenesis and emerging targets of gastric adenocarcinoma.Journal of surgical oncology · 2022Review
- Clinical Relevance of the Tumor Location-Modified Laurén Classification System for Gastric Cancer in a Western Population.Annals of surgical oncology · 2022Article
- The Percentage of Signet Ring Cells Is Inversely Related to Aggressive Behavior and Poor Prognosis in Mixed-Type Gastric Cancer.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
backgroundThe clinicopathological features of mixed-type (MT) early gastric cancer (EGC) according to Lauren's classification remain uninvestigated. This study aimed to clarify the clinicopathological features of MT EGC, particularly in relation to lymph node metastasis (LNM) and long-term survival.
methodsThis study included 5309 patients who underwent gastrectomy for EGC. The clinicopathological features, LNM, and long-term outcomes of patients with MT carcinomas were compared with those of patients with intestinal-type (IT) and diffuse-type (DT) cancers. Furthermore, we evaluated the predictors of LNM in each Lauren classification subgroup.
resultsPatients with MT carcinomas were likelier to have larger tumors, submucosal invasion, lymphovascular invasion, and LNM than those with IT or DT carcinomas. Multivariate logistic regression analysis revealed that the Lauren classification was a significant predictor of LNM (P < 0.001). The significant predictors of LNM in MT carcinomas were female sex, greater tumor size, presence of submucosal invasion, and lymphovascular invasion. However, the overall survival of patients with MT carcinoma was not significantly different from that of patients with IT or DT carcinomas (P = 0.104).
conclusionsThe presence of MT EGC carries a higher risk of LNM compared with the presence of IT or DT carcinomas. Therefore, MT carcinomas should be managed with gastrectomy that includes lymph node dissection instead of endoscopic resection.
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