Evidence map›Paper›PMID 27590322›Full record

ReviewAnalytical and bioanalytical chemistry2017

Glycans and glycoproteins as specific biomarkers for cancer.

Muchena J Kailemia, Dayoung Park, Carlito B Lebrilla

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 5 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 5 syntheses or guidelines pooled it, 332 citations in OpenAlex.

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  20. Altered Cell SurfaceJournal of proteome research · 2025
    Article

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Muchena J KailemiaDepartment of Chemistry, University of California, Davis, CA, 95616, USA.
Dayoung ParkDepartment of Chemistry, University of California, Davis, CA, 95616, USA.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA, 95616, USA. cblebrilla@ucdavis.edu.
University of California, Davis · US

Funding

The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
NCCIH NIH HHS R01 AT007079NCCIH NIH HHS R01 AT008759NIGMS NIH HHS R01 GM049077
6 · The paper itself

Abstract

Protein glycosylation and other post-translational modifications are involved in potentially all aspects of human growth and development. Defective glycosylation has adverse effects on human physiological conditions and accompanies many chronic and infectious diseases. Altered glycosylation can occur at the onset and/or during tumor progression. Identifying these changes at early disease stages may aid in making decisions regarding treatments, as early intervention can greatly enhance survival. This review highlights some of the efforts being made to identify N- and O-glycosylation profile shifts in cancer using mass spectrometry. The analysis of single or panels of potential glycoprotein cancer markers are covered. Other emerging technologies such as global glycan release and site-specific glycosylation analysis and quantitation are also discussed. Graphical Abstract Steps involved in the biomarker discovery.

Indexed as

BiomarkersGlycoproteinsHumansMass SpectrometryNeoplasmsPolysaccharidesProtein Processing, Post-TranslationalBiomarkersGlycoproteinsPolysaccharidesCancerDisease biomarkerGlycomicsGlycoproteomicsMass spectrometrySite-specific glycosylation

Identifiers

PMID27590322
PMCPMC5203967
OpenAlexW2512344700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.