ArticleMolecular neurobiology2017
Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress.Molecular psychiatry · 2025Review
- Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.Scientific reports · 2025Article
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- Relationship of depression and sleep quality, diseases and general characteristics.World journal of psychiatry · 2022Article
- Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression.Frontiers in psychiatry · 2022Article
- The Molecular Basis of Resilience: A Narrative Review.Frontiers in psychiatry · 2022Review
- Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior.Molecular neurobiology · 2021Article
- The Effects and Mechanisms of Exercise on the Treatment of Depression.Frontiers in psychiatry · 2021Review
- Neuroimmune circuits in inter-organ communication.Nature reviews. Immunology · 2020Review
- Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors.Molecular neurobiology · 2019Article
- The immune system and psychiatric disease: a basic science perspective.Clinical and experimental immunology · 2019Review
- Extracellular Vesicles Derived fromExperimental neurobiology · 2019Article
- Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis.Nutrients · 2019Article
- Sociability and Social Novelty Preference Tests Using a U-shaped Two-choice Field.Bio-protocol · 2018Article
- Association between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes-potential differences by diabetes type and depression scores.Translational psychiatry · 2018Article
- Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage.Frontiers in psychiatry · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-18 (IL18) is a multifunctional cytokine that has been implicated in increased susceptibility to depression; however, the underlying mechanism remains unknown. We found that the IL18 system in the basolateral amygdala (BLA) determined susceptibility to chronic stress. Mice subjected to chronic restraint stress or chronic foot-shock stress demonstrated increased expression of IL18 in the BLA, and exhibited depression-like behaviors, whereas IL18 knockout (KO) mice were resilient to these chronic stresses. IL18 and IL18 receptors in the BLA were expressed in glutamatergic and GABAergic neurons in addition to glial cells. Local inhibition of IL18 and IL18 receptors in the BLA by stereotaxic injection of siRNA-IL18 or siRNA-IL18 receptor-1α was sufficient to suppress stress-induced depression-like behaviors. Following chronic stress, the downstream mediator of IL18 receptor activation, phospho-NF-kB, was increased in BLA neurons expressing IL18 receptors. Furthermore, siRNA-mediated inhibition of NF-kB in the BLA significantly suppressed stress-induced depression-like behaviors, and NF-kB KO mice were resilient to chronic stress. The siRNA-mediated inhibition of NF-kB in the BLA downregulated stress-induced increased expression of Hcrt, MCH, OXT, AVP, and TRH, the neuropeptides that were induced by chronic stress in the BLA and promoted depression-like behaviors. These results suggest that the local IL18 and its receptor system in the BLA function as molecular regulators promoting susceptibility to chronic stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.