Evidence map›Paper›PMID 27590053›Full record

ArticleBMC infectious diseases2016

What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England.

Enrique Castro-Sánchez, Luke S P Moore, Fran Husson, Alison H Holmes

Registry-linked trialAbstract read
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04848883 (Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care), which is not on this map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04848883 nacompletednot on this mapstarted 2021, after this paper: background citation

Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care: a Cluster-randomised Blinded Study (IDASP)

TypeinterventionalSponsorInstitut d'Investigació Biomèdica de BellvitgeRan2021 to 2024Enrolled1,389ConditionsInfectious DiseaseArmsAdvanced AMS program, Standard AMS program
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  15. The biological functions ofFrontiers in veterinary science · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Enrique Castro-SánchezNational Institute of Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, London, W12 0NN, UK. e.castro-sanchez@imperial.ac.uk.ORCID 0000-0002-3351-9496
Luke S P MooreNational Institute of Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.
Fran HussonImperial College Healthcare NHS Trust, London, UK.
Alison H HolmesNational Institute of Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance is driven by multiple factors. Resolving the threat to human and animal health presented by drug-resistant infections remains a societal challenge that demands close collaboration between scientists and citizens. We compared current public views about key contributing factors to antimicrobial resistance with those expressed by experts.

methodsOverarching factors contributing to antimicrobial resistance were identified following a review of literature. The factors were then described in plain language and attached to ballot boxes at a public engagement event organised by a university. Responses to each factor were counted at the end of the event.

resultsFour hundred five responses were received from 3750 visitors (11 % response rate). Nearly half of responses (192/405, 47 · 4 %) considered the misuse/overuse of antibiotics in humans as the main determinant of antimicrobial resistance. The misuse of antibiotics in animal health obtained 16 · 3 % (66/405) responses. However, the lack of quick tests to diagnose infections received 10/405 votes (2 · 47 %), and the lack of effective vaccines received one vote (0 · 25 %).

conclusionsThe majority of responses ascribed the emergence of drug-resistant infections to the misuse of antibiotics in human and animals. Suboptimal dosing, availability of diagnostics and environmental contamination were considered less influential on the development of antimicrobial resistance. The growing recognition of broader multifaceted drivers of drug resistance by experts is not yet echoed in the public mind.

Indexed as

Drug Resistance, MicrobialAnimalsAnti-Bacterial AgentsHumansLondonPrescription Drug MisusePublic OpinionAnti-Bacterial AgentsAntimicrobial resistanceHealth literacyPublic awareness

Identifiers

PMID27590053
PMCPMC5010725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.