ArticlePediatric nephrology (Berlin, Germany)2017
International validation of a urinary biomarker panel for identification of active lupus nephritis in children.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Pathogenesis, Treatment Advances, and Renal Outcomes in Childhood-Onset Lupus Nephritis.Clinical pediatrics · 2026Review
- Evaluation of probiotic potential of bacteria isolated from black tiger (Penaeus monodon) for aquaculture application.Journal, genetic engineering & biotechnology · 2026Article
- Management of childhood-onset systemic lupus erythematosus (cSLE) over the last two decades in Spain.Pediatric rheumatology online journal · 2025Review
- Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis.Rheumatology (Oxford, England) · 2023Article
- Clinical measurement of lupus nephritis activity is inferior to biomarker-based activity assessment using the renal activity index for lupus nephritis in childhood-onset systemic lupus erythematosus.Lupus science & medicine · 2022Article
- Diagnostic test accuracy of novel biomarkers for lupus nephritis-An overview of systematic reviews.PloS one · 2022Review
- Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus.Frontiers in immunology · 2022Article
- Article
- A panel of urinary proteins predicts active lupus nephritis and response to rituximab treatment.Rheumatology (Oxford, England) · 2021Article
- Successful Urine Multiplex Bead Assay to Measure Lupus Nephritis Activity.Kidney international reports · 2021Article
- Kidney outcomes for children with lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2021Review
- Urinary ferritin creatinine ratio, a potential biomarker for lupus nephritis activity.Clinical rheumatology · 2021Article
- Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus.Frontiers in immunology · 2021Review
- The utility of urinary biomarker panel in predicting renal pathology and treatment response in Chinese lupus nephritis patients.PloS one · 2020Article
- Proteomic profiling of urine: implications for lupus nephritis.Expert review of proteomics · 2019Review
- A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.Clinical immunology (Orlando, Fla.) · 2019Article
- Podocytes contribute, and respond, to the inflammatory environment in lupus nephritis.American journal of physiology. Renal physiology · 2018Article
- A downstream molecule of 1,25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis.Scientific reports · 2018Article
- Urinary clusterin-a novel urinary biomarker associated with pediatric lupus renal histopathologic features and renal survival.Pediatric nephrology (Berlin, Germany) · 2018Article
- Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2018Article
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundConventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic accuracy. The aim of this study was to assess the performance of a biomarker panel to identify active LN in two international JSLE cohorts.
methodsNovel urinary biomarkers, namely vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), lipocalin-like prostaglandin D synthase (LPGDS), transferrin (TF), ceruloplasmin, alpha-1-acid glycoprotein (AGP) and neutrophil gelatinase-associated lipocalin (NGAL), were quantified in a cross-sectional study that included participants of the UK JSLE Cohort Study (Cohort 1) and validated within the Einstein Lupus Cohort (Cohort 2). Binary logistic regression modelling and receiver operating characteristic curve analysis [area under the curve (AUC)] were used to identify and assess combinations of biomarkers for diagnostic accuracy.
resultsA total of 91 JSLE patients were recruited across both cohorts, of whom 31 (34 %) had active LN and 60 (66 %) had no LN. Urinary AGP, ceruloplasmin, VCAM-1, MCP-1 and LPGDS levels were significantly higher in those patients with active LN than in non-LN patients [all corrected p values (p
conclusionIn two international JSLE cohorts, urinary AGP, ceruloplasmin, LPGDS and TF demonstrate an 'excellent' ability for accurately identifying active LN in children.
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