ArticleOncotarget2016
The rate of change in declining steroid hormones: a new parameter of healthy aging in men?
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A meta-analysis of the association between male dimorphism and fitness outcomes in humans.eLife · 2022Pooled it
- Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis.JAMA psychiatry · 2019Pooled it
- A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.American journal of men's healthTrial
- No Relevant Associations Between Markers of Smoking Behaviour and Plasma Progesterone Concentrations: Findings From a Sex-Stratified Cohort Study.Addiction biology · 2025Article
- Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger patients.BMC psychiatry · 2025Observational
- Article
- A literature review onHeliyon · 2023Review
- Testosterone Replacement Therapy in the Treatment of Depression.Health psychology research · 2022Article
- The Role of Sex Hormones on Bone Mineral Density, Marrow Adiposity, and Muscle Adiposity in Middle-Aged and Older Men.Frontiers in endocrinology · 2022Article
- Reduced renal function may explain the higher prevalence of hyperuricemia in older people.Scientific reports · 2021Article
- Optimization of mass spectrometry settings for steroidomic analysis in young and old killifish.Analytical and bioanalytical chemistry · 2020Article
- Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?The world journal of men's health · 2020Review
- The Relation Between Steroid Secretion Patterns and the Androgen Receptor Gene Polymorphism on Physical Health and Psychological Well-Being-Longitudinal Findings From the Men's Health 40+ Study.Frontiers in human neuroscience · 2020Article
- Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.Psychoneuroendocrinology · 2019Article
- MR-10 Enhances Men's Health by Improving Endogenous Male Sex Hormone Generation.Journal of medicinal food · 2018Article
- The poly-omics of ageing through individual-based metabolic modelling.BMC bioinformatics · 2018Article
- Article
- Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.Investigative ophthalmology & visual science · 2018Article
- Commentary: Physical Functional Capacity and C-Reactive Protein in Schizophrenia.Frontiers in psychiatry · 2018Article
- Psychobiological Protective Factors Modifying the Association Between Age and Sexual Health in Men: Findings From the Men's Health 40+ Study.American journal of men's health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on healthy aging in men has increasingly focused on age-related hormonal changes. Testosterone (T) decline is primarily investigated, while age-related changes in other sex steroids (dehydroepiandrosterone [DHEA], estradiol [E2], progesterone [P]) are mostly neglected. An integrated hormone parameter reflecting aging processes in men has yet to be identified. 271 self-reporting healthy men between 40 and 75 provided both psychometric data and saliva samples for hormone analysis. Correlation analysis between age and sex steroids revealed negative associations for the four sex steroids (T, DHEA, E2, and P). Principal component analysis including ten salivary analytes identified a principal component mainly unifying the variance of the four sex steroid hormones. Subsequent principal component analysis including the four sex steroids extracted the principal component of declining steroid hormones (DSH). Moderation analysis of the association between age and DSH revealed significant moderation effects for psychosocial factors such as depression, chronic stress and perceived general health. In conclusion, these results provide further evidence that sex steroids decline in aging men and that the integrated hormone parameter DSH and its rate of change can be used as biomarkers for healthy aging in men. Furthermore, the negative association of age and DSH is moderated by psychosocial factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.