Evidence map›Paper›PMID 27589826›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Predonation Prescription Opioid Use: A Novel Risk Factor for Readmission After Living Kidney Donation.

K L Lentine, N N Lam, M A Schnitzler, G P Hess, B L Kasiske, H Xiao, D Axelrod, A X Garg, J D Schold, H Randall and 3 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Survival implications of prescription opioid and benzodiazepine use in lung transplant recipients: Analysis of linked transplant registry and pharmacy fill records.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Article
  6. Opioids and Kidney Transplantation.Seminars in nephrology · 2021
    Review
  7. Article
  8. Article
  9. Prescription opioid use before and after heart transplant: Associations with posttransplant outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  10. Article
  11. Article
  12. Prescription opioid use before and after kidney transplant: Implications for posttransplant outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

K L LentineCenter for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, MO.
N N LamDivision of Nephrology, University of Alberta, Edmonton, AB, Canada.
M A SchnitzlerCenter for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, MO.
G P HessSymphony Health, Pittsburgh, PA.
B L KasiskeDivision of Nephrology, Hennepin County Medical Center, Minneapolis, MN.
H XiaoCenter for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, MO.
D AxelrodDivision of Abdominal Transplantation, Department of Surgery, Brody School of Medicine, Greenville, NC.
A X GargDivision of Nephrology, Western University, London, ON, Canada.
J D ScholdDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
H RandallCenter for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, MO.
N DzebisashviliDickson Advanced Analytics, Carolinas HealthCare System, Charlotte, NC.
D C BrennanTransplant Nephrology, Washington University School of Medicine, St. Louis, MO.
D L SegevDivision of Transplantation, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
Saint Louis University · USCarolinas Healthcare System · USCleveland Clinic · USEast Carolina University · USHennepin County Medical Center · USJohns Hopkins Medicine · USUniversity of Alberta · CAUniversity of Pennsylvania · USWashington University in St. Louis · USWestern University · CA

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

Implications of opioid use in living kidney donors for key outcomes, including readmission rates after nephrectomy, are unknown. We integrated Scientific Registry of Transplant Recipients data with records from a nationwide pharmacy claims warehouse and administrative records from an academic hospital consortium to quantify predonation prescription opioid use and postdonation readmission events. Associations of predonation opioid use (adjusted odds ratio [aOR]) in the year before donation and other baseline clinical, procedural, and center factors with readmission within 90 days postdonation were examined by using multivariate logistic regression. Among 14 959 living donors, 11.3% filled one or more opioid prescriptions in the year before donation. Donors with the highest level of predonation opioid use (>305 mg/year) were more than twice as likely as nonusers to be readmitted (6.8% vs. 2.6%; aOR 2.49, 95% confidence interval 1.74-3.58). Adjusted readmission risk was also significantly (p < 0.05) higher for women (aOR = 1.25), African Americans (aOR = 1.45), spouses (aOR = 1.42), exchange participants (aOR = 1.46), uninsured donors (aOR = 1.40), donors with predonation estimated glomerular filtration rate <60 mL/min/1.73 m

Indexed as

Living DonorsAdultAnalgesics, OpioidDrug PrescriptionsFemaleFollow-Up StudiesGlomerular Filtration RateGraft SurvivalHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleNephrectomyPatient ReadmissionPrognosisAnalgesics, Opioiddonors and donation: livingepidemiologyhealth services and outcomes researchkidney transplantation/nephrologyregistry/registry analysisrisk assessment/risk stratification

Identifiers

PMID27589826
PMCPMC12317785
OpenAlexW2511552817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.