Evidence map›Paper›PMID 27589803›Full record

ReviewCancers2016

Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer.

Alanna E Sedgwick, Crislyn D'Souza-Schorey

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 84 citations in OpenAlex.

  1. MultilevelCurrent research in structural biology · 2026
    Article
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  3. Review
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  5. Article
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  7. Review
  8. Seryl-tRNA synthetase inhibits Wnt signaling and breast cancer progression and metastasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells.International journal of molecular sciences · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alanna E SedgwickDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA. Alanna.E.Sedgwick.1@nd.edu.
Crislyn D'Souza-SchoreyDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA. cdsouzas@nd.edu.
University of Notre Dame · US

Funding

Molecular Mechanisms of Cell InvasionR01CA115316 · NCI · UNIVERSITY OF NOTRE DAME · PI D'SOUZA-SCHOREY, CRISLYN · 2011 to 2016
$1.5M
NCI NIH HHS R01 CA115316
6 · The paper itself

Abstract

The importance of canonical and non-canonical Wnt signal transduction cascades in embryonic development and tissue homeostasis is well recognized. The aberrant activation of these pathways in the adult leads to abnormal cellular behaviors, and tumor progression is frequently a consequence. Here we discuss recent findings and analogies between Wnt signaling in developmental processes and tumor progression, with a particular focus on cell motility and matrix invasion and highlight the roles of the ARF (ADP-Ribosylation Factor) and Rho-family small GTP-binding proteins. Wnt-regulated signal transduction from cell surface receptors, signaling endosomes and/or extracellular vesicles has the potential to profoundly influence cell movement, matrix degradation and paracrine signaling in both development and disease.

Indexed as

cancercell invasioncell motilitydevelopmentsmall GTP-binding proteinsWnts

Identifiers

PMID27589803
PMCPMC5040982
OpenAlexW2516986218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.