ArticleMolecules (Basel, Switzerland)2016
Purification of Flavonoids from Chinese Bayberry (Morella rubra Sieb. et Zucc.) Fruit Extracts and α-Glucosidase Inhibitory Activities of Different Fractionations.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 28 citations in OpenAlex.
- Valorization of Bayberry (Plants (Basel, Switzerland) · 2026Article
- Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies.Natural products and bioprospecting · 2024Review
- Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation inHorticulture research · 2022Article
- An overview of the nutritional value, health properties, and future challenges of Chinese bayberry.PeerJ · 2022Review
- Genome-wide analysis of UDP-glycosyltransferase gene family and identification of members involved in flavonoid glucosylation in Chinese bayberry (Frontiers in plant science · 2022Article
- Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro.PloS one · 2021Article
- α-Glucosidase inhibitors from Chinese bayberry (RSC advances · 2020Article
- Comparison of Phytochemical Differences of the Pulp of Different Peach [Molecules (Basel, Switzerland) · 2019Article
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7 authors at 1 institution in 1 country.
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Abstract
Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1), myricetin-3-O-rhamnoside (2), quercetin-3-O-galactoside (3), quercetin-3-O-rhamnoside (4), from Chinese bayberry pulp was established by the combination of solid phase extract (SPE) by C18 Sep-Pak(®) cartridge column chromatography and semi-preparative HPLC (Prep-HPLC), which was followed by HPLC and LC-MS identification. The purified flavonoid glycosides, as well as different fractions of fruit extracts of six bayberry cultivars, were investigated for α-glucosidase inhibitory activities. The flavonol extracts (50% methanol elution fraction) of six cultivars showed strong α-glucosidase inhibitory activities (IC50 = 15.4-69.5 μg/mL), which were higher than that of positive control acarbose (IC50 = 383.2 μg/mL). Four purified compounds 1-4 exerted α-glucosidase inhibitory activities, with IC50 values of 1444.3 μg/mL, 418.8 μg/mL, 556.4 μg/mL, and 491.8 μg/mL, respectively. Such results may provide important evidence for the potential anti-diabetic activity of different cultivars of Chinese bayberry fruit and the possible bioactive compounds involved.
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