ReviewNeurobiology of stress2015
Social inequalities in health in nonhuman primates.
Review in Neurobiology of stress, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Increased Mortality Despite Successful Multifactorial Cardiovascular Risk Reduction in Healthy Men: 40-Year Follow-Up of the Helsinki Businessmen Study Intervention Trial.The journal of nutrition, health & aging · 2018Trial
- Individual differences in sociocognitive traits in semi-free-ranging rhesus monkeys (Macaca mulatta).American journal of primatology · 2025Article
- Improving Reproductive Success in Captive Marmosets Through Active Female Choice.American journal of primatology · 2025Article
- Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.Frontiers in nutrition · 2025Article
- Social status as a latent variable in the amygdala of observers of social interactions.Neuron · 2024Article
- Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis).Brain, behavior, and immunity · 2024Article
- Aging, Race, and Health Disparities: Recommendations From the Research Centers Collaborative Network.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Estimating the cardiac signals of chimpanzees using a digital camera: validation and application of a novel non-invasive method for primate research.Behavior research methods · 2024Article
- Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys.Psychopharmacology · 2024Article
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Differential effects of western versus mediterranean diets and psychosocial stress on ovarian function in female monkeys (Macaca fascicularis).Psychoneuroendocrinology · 2023Article
- Delay discounting as a behavioral phenotype associated with social rank in female and male cynomolgus monkeys: Correlation with kappa opioid receptor availability.Pharmacology, biochemistry, and behavior · 2023Article
- Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine-like procedures for rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta).PloS one · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- Mediterranean Diet Reduces Social Isolation and Anxiety in Adult Female Nonhuman Primates.Nutrients · 2022Article
- Psychosocial stress increases risk for type 2 diabetes in female cynomolgus macaques consuming a western diet.Psychoneuroendocrinology · 2022Article
- Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment.Heliyon · 2021Article
- Article
- Mediterranean diet, stress resilience, and aging in nonhuman primates.Neurobiology of stress · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Overall health has been linked to socioeconomic status, with the gap between social strata increasing each year. Studying the impact of social position on health and biological functioning in nonhuman primates has allowed researchers to model the human condition while avoiding ethical complexities or other difficulties characteristic of human studies. Using female cynomolgus macaques (Macaca fascicularis), our lab has examined the link between social status and stress for 30 years. Female nonhuman primates are especially sensitive to social stressors which can deleteriously affect reproductive health, leading to harmful consequences to their overall health. Subordinates have lower progesterone concentrations during the luteal phase of menstrual cycle, which is indicative of absence or impairment of ovulation. Subordinate animals receive more aggression, less affiliative attention, and are more likely to exhibit depressive behaviors. They also express higher stress-related biomarkers such as increased heart rates and lower mean cortisol. While no differences in body weight between dominant and subordinate animals are observed, subordinates have lower bone density and more visceral fat than their dominant counterparts. The latter increases risk for developing inflammatory diseases. Differences are also observed in neurological and autonomic function. A growing body of data suggests that diet composition may amplify or diminish physiological stress responses which have deleterious effects on health. More experimental investigation of the health effects of diet pattern is needed to further elucidate these differences in an ongoing search to find realistic and long-term solutions to the declining health of individuals living across the ever widening socioeconomic spectrum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.