ReviewCurrent opinion in neurobiology2016
Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.
Review in Current opinion in neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Changes in cardio-respiratory-vascular coupling dynamics across altitude gradients: a shift from linear synchrony to nonlinear complexity.Frontiers in physiology · 2026Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors.bioRxiv : the preprint server for biology · 2024Article
- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Revisiting the two rhythm generators for respiration in lampreys.Frontiers in neuroanatomy · 2023Article
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- A direct excitatory action of lactate ions in the central respiratory network of bullfrogs,The Journal of experimental biology · 2020Article
- Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.eLife · 2019Article
- A spatially dynamic network underlies the generation of inspiratory behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cholinergic neurons in the pedunculopontine tegmental nucleus modulate breathing in rats by direct projections to the retrotrapezoid nucleus.The Journal of physiology · 2019Article
- Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.PLoS biology · 2019Article
- Defining the Rhythmogenic Elements of Mammalian Breathing.Physiology (Bethesda, Md.) · 2018Review
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Organization of the core respiratory network: Insights from optogenetic and modeling studies.PLoS computational biology · 2018Article
- The interdependence of excitation and inhibition for the control of dynamic breathing rhythms.Nature communications · 2018Article
- Phylogenetically persistent purinergic modulation of central pattern generators for breathing in lamprey and mammals.The Journal of physiology · 2017Article
- ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey.The Journal of physiology · 2017Article
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Transcriptome of neonatal preBötzinger complex neurones in Dbx1 reporter mice.Scientific reports · 2017Article
- Morphology of Dbx1 respiratory neurons in the preBötzinger complex and reticular formation of neonatal mice.Scientific data · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Rhythmicity is critical for the generation of rhythmic behaviors and higher brain functions. This review discusses common mechanisms of rhythm generation, including the role of synaptic inhibition and excitation, with a focus on the mammalian respiratory network. This network generates three phases of breathing and is highly integrated with brain regions associated with numerous non-ventilatory behaviors. We hypothesize that during evolution multiple rhythmogenic microcircuits were recruited to accommodate the generation of each breathing phase. While these microcircuits relied primarily on excitatory mechanisms, synaptic inhibition became increasingly important to coordinate the different microcircuits and to integrate breathing into a rich behavioral repertoire that links breathing to sensory processing, arousal, and emotions as well as learning and memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.