ArticlePloS one2016
Genomic and Metabolomic Profile Associated to Clustering of Cardio-Metabolic Risk Factors.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study.Redox biology · 2022Article
- Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals.Metabolites · 2022Article
- Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.Pediatric research · 2022Observational
- Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease.Molecules (Basel, Switzerland) · 2021Article
- Clinical and lifestyle related factors influencing whole blood metabolite levels - A comparative analysis of three large cohorts.Molecular metabolism · 2019Article
- Article
- The Future of "Omics" in Hypertension.The Canadian journal of cardiology · 2017Review
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Authors and funding
12 authors.
Funding
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Abstract
backgroundTo identify metabolomic and genomic markers associated with the presence of clustering of cardiometabolic risk factors (CMRFs) from a general population. METHODS AND
findingsOne thousand five hundred and two subjects, Caucasian, > 18 years, representative of the general population, were included. Blood pressure measurement, anthropometric parameters and metabolic markers were measured. Subjects were grouped according the number of CMRFs (Group 1: <2; Group 2: 2; Group 3: 3 or more CMRFs). Using SNPlex, 1251 SNPs potentially associated to clustering of three or more CMRFs were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54±19, 50.6% men) with high genotyping call rate were analysed. A differential metabolomic profile, which included products from mitochondrial metabolism, extra mitochondrial metabolism, branched amino acids and fatty acid signals were observed among the three groups. The comparison of metabolomic patterns between subjects of Groups 1 to 3 for each of the genotypes associated to those subjects with three or more CMRFs revealed two SNPs, the rs174577_AA of FADS2 gene and the rs3803_TT of GATA2 transcription factor gene, with minimal or no statistically significant differences. Subjects with and without three or more CMRFs who shared the same genotype and metabolomic profile differed in the pattern of CMRFS cluster. Subjects of Group 3 and the AA genotype of the rs174577 had a lower prevalence of hypertension compared to the CC and CT genotype. In contrast, subjects of Group 3 and the TT genotype of the rs3803 polymorphism had a lower prevalence of T2DM, although they were predominantly males and had higher values of plasma creatinine.
conclusionsThe results of the present study add information to the metabolomics profile and to the potential impact of genetic factors on the variants of clustering of cardiometabolic risk factors.
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