ArticlePloS one2016
Functional and Psychosocial Outcomes of Hand Transplantation Compared with Prosthetic Fitting in Below-Elbow Amputees: A Multicenter Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Challenges and opportunities in vascularized composite allotransplantation of joints: a systematic literature review.Frontiers in immunology · 2023Pooled it
- Bibliometric analysis of limb replantation and transplantation: global research trends and hotspots (2001-2025).Annals of medicine and surgery (2012) · 2026Article
- Proximal Bilateral Arm Transplantation with Left Shoulder Reconstruction: Outcomes at 24 Months.Plastic and reconstructive surgery. Global open · 2024Article
- Article
- Methods of ex vivo analysis of tissue status in vascularized composite allografts.Journal of translational medicine · 2023Review
- Patient definitions of transplant success in upper extremity vascularized composite allotransplantation: A mixed-methods study.SAGE open medicine · 2023Article
- Bionic Prostheses: The Emerging Alternative to Vascularised Composite Allotransplantation of the Limb.Frontiers in surgery · 2022Review
- Education for patients with limb loss or absence: Aging, overuse concerns, and patient treatment knowledge gaps.Frontiers in psychology · 2022Article
- Assessment of quality of life after upper extremity transplantation: Framework for patient-reported outcome scale domains.Frontiers in psychology · 2022Article
- Hand Transplantation-Risks and Benefits.Journal of hand and microsurgery · 2021Review
- Outcome of Early Motion Protocol for Total Hand Replantation: 1- and 2-Year Postoperative Results.Journal of hand and microsurgery · 2020Article
- MUW researcher of the month.Wiener klinische Wochenschrift · 2020Article
- Bionic reconstruction : Restoration of extremity function with osseointegrated and mind-controlled prostheses.Wiener klinische Wochenschrift · 2019Article
- Evolving ethics, policy and reimbursement issues of vascularized composite allotransplantation: Symposium summary.SAGE open medicine · 2019Article
- Social, economic, and policy implications of organ preservation advances.Current opinion in organ transplantation · 2018Review
- The Vienna psychosocial assessment procedure for bionic reconstruction in patients with global brachial plexus injuries.PloS one · 2018Article
- Outcomes after hand and upper extremity transplantation.Journal of materials science. Materials in medicine · 2017Review
- Health care costs of major upper-extremity amputations in Ontario: a retrospective matched-cohort analysis with considerations for transplantation.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHand-transplantation and improvements in the field of prostheses opened new frontiers in restoring hand function in below-elbow amputees. Both concepts aim at restoring reliable hand function, however, the indications, advantages and limitations for each treatment must be carefully considered depending on level and extent of amputation. Here we report our findings of a multi-center cohort study comparing hand function and quality-of-life of people with transplanted versus prosthetic hands.
methodsHand function in amputees with either transplant or prostheses was tested with Action Research Arm Test (ARAT), Southampton Hand Assessment Procedure (SHAP) and the Disabilities of the Arm, Shoulder and Hand measure (DASH). Quality-of-life was compared with the Short-Form 36 (SF-36).
resultsTransplanted patients (n = 5) achieved a mean ARAT score of 40.86 ± 8.07 and an average SHAP score of 75.00 ± 11.06. Prosthetic patients (n = 7) achieved a mean ARAT score of 39.00 ± 3.61 and an average SHAP score of 75.43 ± 10.81. There was no significant difference between transplanted and prosthetic hands in ARAT, SHAP or DASH. While quality-of-life metrics were equivocal for four scales of the SF-36, transplanted patients reported significantly higher scores in "role-physical" (p = 0.006), "vitality" (p = 0.008), "role-emotional" (p = 0.035) and "mental-health" (p = 0.003).
conclusionsThe indications for hand transplantation or prosthetic fitting in below-elbow amputees require careful consideration. As functional outcomes were not significantly different between groups, patient's best interests and the route of least harm should guide treatment. Due to the immunosuppressive side-effects, the indication for allotransplantation must still be restrictive, the best being bilateral amputees.
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