ArticleArthritis & rheumatology (Hoboken, N.J.)2017
Multiple Nonspecific Sites of Joint Pain Outside the Knees Develop in Persons With Knee Pain.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Longitudinal study of knee pain amongst workers in the Cultural and Psychosocial Influences on Disability (CUPID) study.BMC musculoskeletal disorders · 2025Article
- High Prevalence of Cold Intolerance in Rheumatoid Arthritis: A Case-Control Study.Clinical case reports · 2025Article
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study.Arthritis care & research · 2024Observational
- Multiple joint osteoarthritis (MJOA): What's in a name?Osteoarthritis and cartilage · 2024Review
- The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.The journal of pain · 2023Observational
- Modifiable physical and behavioural factors associated with widespread pain in older adults with radiographic evidence of knee osteoarthritis.Musculoskeletal care · 2023Article
- Depressive symptoms and multi-joint pain partially mediate the relationship between obesity and opioid use in people with knee osteoarthritis.Osteoarthritis and cartilage · 2022Article
- Article
- Association of Biomarkers with Individual and Multiple Body Sites of Pain: The Johnston County Osteoarthritis Project.Journal of pain research · 2022Article
- Foot and ankle pain and risk of incident knee osteoarthritis and knee pain: Data from the Multicentre Osteoarthritis Study.Osteoarthritis and cartilage open · 2021Article
- Effect of Heeled Shoes on Joint Symptoms and Knee Osteoarthritis in Older Adults: A 5-Year Follow-Up Study.ACR open rheumatology · 2021Article
- Incidence and progression of ankle osteoarthritis: The johnston county osteoarthritis project.Seminars in arthritis and rheumatism · 2021Article
- The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study.Rheumatology (Oxford, England) · 2020Article
- Association of Visceral Adiposity With Pain but Not Structural Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2020Observational
- miR-195 contributes to human osteoarthritis via targeting PTHrP.Journal of bone and mineral metabolism · 2019Article
- Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.Osteoarthritis and cartilage · 2018Article
- Mechanisms for Joint Pain in Rheumatoid Arthritis (RA): from Cytokines to Central Sensitization.Current osteoporosis reports · 2018Review
- Changes in Pain Sensitization After Bariatric Surgery.Arthritis care & research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveMany persons with knee pain have joint pain outside the knee, but despite the impact and high frequency of this pain, its distribution and causes have not been studied. We undertook this study to test the hypothesis of those studying gait abnormalities who have suggested that knee pain causes pain in adjacent joints but that pain adaptation strategies are highly individualized.
methodsWe studied persons ages 50-79 years with or at high risk of knee osteoarthritis who were recruited from 2 community-based cohorts, the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative, and we followed them up for 5-7 years. We excluded those with knee pain at baseline and compared those who had developed knee pain at the first follow-up examination (the index visit) with those who had not. We examined pain on most days at joint regions outside the knee in examinations after the index visit. Logistic regression analyses examined the risk of joint-specific pain adjusted for age, sex, body mass index, and symptoms of depression, and we performed sensitivity analyses excluding those with widespread pain.
resultsIn the combined cohorts, 693 persons had knee pain at the index visit and 2,793 did not. A total of 79.6% of those with bilateral knee pain and 63.8% of those with unilateral knee pain had pain during follow-up in a joint region outside the knee, compared with 49.9% of those without knee pain. There was an increased risk of pain at most extremity joint sites, without a predilection for specific sites. Results were unchanged when those with widespread pain were excluded.
conclusionPersons with chronic knee pain are at increased risk of pain in multiple joints in no specific pattern.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.