Evidence map›Paper›PMID 27588599›Full record

ArticleMolecular cell2016

mTORC2 Puts Its Shoulder to Krebs' Wheel.

Sebastian I Arriola Apelo, Dudley W Lamming

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. The central moTOR of metabolism.Developmental cell · 2022
    Review
  4. Review
  5. Lysosome: The metabolic signaling hub.Traffic (Copenhagen, Denmark) · 2019
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sebastian I Arriola ApeloDepartment of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address: dlamming@medicine.wisc.edu.

Funding

The in vivo regulation of glucose homeostasis and lifespan by mTORC2R00AG041765 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2014 to 2016
$738k
NIA NIH HHS R00 AG041765
6 · The paper itself

Abstract

In this issue of Molecular Cell, Moloughney et al. (2016) find that mTORC2 responds to falling levels of glucose and glutamine catabolites, promoting glutaminolysis and preserving the TCA cycle and hexosamine biosynthesis.

Indexed as

GlutamineShoulderHumansMechanistic Target of Rapamycin Complex 2Multiprotein ComplexesTOR Serine-Threonine KinasesGlutamineMechanistic Target of Rapamycin Complex 2Multiprotein ComplexesTOR Serine-Threonine Kinases

Identifiers

PMID27588599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.