Evidence map›Paper›PMID 27588485›Full record

ArticleOncotarget2016

Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features.

Sea-Won Lee, Kyung Hwan Shin, Eui Kyu Chie, Jin Ho Kim, Seock-Ah Im, Wonshik Han, Dong-Young Noh, Hyeon Woo Lim, Tae Hyun Kim, Keun Seok Lee and 3 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sea-Won LeeSeoul National University, College of Medicine, Seoul, Korea.
Kyung Hwan ShinSeoul National University, College of Medicine, Seoul, Korea.
Eui Kyu ChieSeoul National University, College of Medicine, Seoul, Korea.
Jin Ho KimSeoul National University, College of Medicine, Seoul, Korea.
Seock-Ah ImSeoul National University, College of Medicine, Seoul, Korea.
Wonshik HanSeoul National University, College of Medicine, Seoul, Korea.
Dong-Young NohSeoul National University, College of Medicine, Seoul, Korea.
Hyeon Woo LimResearch Institute and Hospital, National Cancer Center, Goyang, Korea.
Tae Hyun KimResearch Institute and Hospital, National Cancer Center, Goyang, Korea.
Keun Seok LeeResearch Institute and Hospital, National Cancer Center, Goyang, Korea.
Eun Sook LeeResearch Institute and Hospital, National Cancer Center, Goyang, Korea.
Soo Yoon SungCatholic University of Korea, College of Medicine, Seoul, Korea.
Kyubo KimEwha Womans University, School of Medicine, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccelerated whole breast irradiation (AWBI) and conventional whole breast irradiation (CWBI) were compared to determine whether AWBI is as effective as CWBI in patients with early breast cancer and adverse prognostic features. PATIENTS AND

methodsWe included 330 patients who underwent breast-conserving surgery (BCS) and post-operative radiation therapy (RT) using AWBI for pT1-2 and pN0-1a breast cancer from 2007 to 2010. These patients were matched with 330 patients who received CWBI according to stage, age (±3 years), and the year of BCS. AWBI of 39 Gy and CWBI of 50.4 Gy were given in 13 and 28 fractions, respectively.

resultsMedian follow-up time was 81.9 months. There were no statistically significant differences between the AWBI and CWBI groups in terms of age, stage, tumor grade, or molecular subtype. More patients with Ki-67 index ≥ 14% were present in the AWBI group (AWBI 47.0% vs. CWBI 10.3%; P<0.01). The 5-year ipsilateral breast tumor relapse (IBTR) rates for the AWBI and CWBI groups were 0.8% and 1.8%, respectively (P=0.54). High tumor grade was a statistically significant risk factor for IBTR (5-year IBTR rate: 2.9%; P=0.01). Ki-67 ≥ 14% was marginally related to IBTR (5-year IBTR rate: 2.2%; P=0.07). There were no statistically significant differences in the hazard ratios between the AWBI and CWBI groups according to any of the risk factors. There were no acute grade 3 toxicities in the AWBI group. There were no late grade 3 toxicities in either group.

conclusionsAWBI is comparable to CWBI in early breast cancer with adverse prognostic features.

Indexed as

Dose Fractionation, RadiationAdultAgedAged, 80 and overBreast NeoplasmsDisease-Free SurvivalDisease ProgressionFemaleHumansKi-67 AntigenMastectomy, SegmentalMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingRadiotherapy, AdjuvantKi-67 Antigenearly breast cancerhypofractionationrisk factor

Identifiers

PMID27588485
PMCPMC5348439

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.