Evidence map›Paper›PMID 27588465›Full record

ArticleOncotarget2016

Validation of the Memorial Sloan Kettering Cancer Center nomogram to predict disease-specific survival in a Chinese gastric cancer population receiving postoperative chemoradiotherapy after an R0 resection.

Meng-Long Zhou, Lei Wang, Jia-Zhou Wang, Wang Yang, Ran Hu, Gui-Chao Li, Wei-Qi Sheng, Zhen Zhang

Open access · diamondAbstract readValidation Study
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Meng-Long ZhouDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Lei WangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Jia-Zhou WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Wang YangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Ran HuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Gui-Chao LiDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Wei-Qi ShengDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Zhen ZhangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widely validated Memorial Sloan Kettering Cancer Center (MSKCC) nomogram for gastric carcinoma (GC) was developed based on patients who received R0 resection only. The purpose of the current study was to assess the performance of this nomogram in Chinese patients who received postoperative chemoradiotherapy (CRT) after an R0 resection for GC. From 2006 to 2015, the clinical data of 150 eligible patients were retrospectively collected from the Fudan University Shanghai Cancer Center (FUSCC) and used for external validation. The nomogram was validated by means of the concordance index (CI) and a calibration plot. The CI for the nomogram was 0.657, which was lower than the CI of the nomogram for patients who received surgery alone (0.80). In the calibration plot, the gap between the observed and the predicted survival gradually increased as the predicted 5-year disease-specific survival (DSS) decreased. Thus the MSKCC nomogram for GC significantly underestimated the survival of patients in the FUSCC cohort, especially the survival of patients whose predicted 5-year DSS was less than 50%. The current study indicates the potential for the nomogram to be developed as an ideal tool to identify target patients for postoperative CRT.

Indexed as

ChemoradiotherapyGastrectomyNomogramsAdultAgedChinaCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient SelectionPostoperative PeriodPrognosisRetrospective Studiesgastric carcinomanomogrampatient selectionpostoperative chemoradiationprognosis

Identifiers

PMID27588465
PMCPMC5323113
OpenAlexW2515380678

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.