ArticlePloS one2016
Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Cap-to-bell stage molar tooth morphogenesis occurs through proliferation-independent sulcus sharpening and condensation-associated tension in the dental papilla.Journal of anatomy · 2025Article
- Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro.Dentistry journal · 2024Article
- Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal.Journal of visualized experiments : JoVE · 2023Article
- Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.Nature communications · 2023Article
- Engineering multicellular living systems-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2022Article
- Tracing the developmental origin of tissue stem cells.Development, growth & differentiation · 2022Review
- Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia.Science advances · 2022Article
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Tracing the origin of hair follicle stem cells.Nature · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
- Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition.Scientific reports · 2020Article
- Live Tissue Imaging Sheds Light on Cell Level Events During Ectodermal Organ Development.Frontiers in physiology · 2020Review
- Molar Bud-to-Cap Transition Is Proliferation Independent.Journal of dental research · 2019Article
- Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis.Scientific reports · 2019Article
- Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study.PLoS computational biology · 2018Article
- Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers.The Journal of biological chemistry · 2017Article
- From snapshots to movies: Understanding early tooth development in four dimensions.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphologies of ectodermal organs are shaped by appropriate combinations of several deformation modes, such as invagination and anisotropic tissue elongation. However, how multicellular dynamics are coordinated during deformation processes remains to be elucidated. Here, we developed a four-dimensional (4D) analysis system for tracking cell movement and division at a single-cell resolution in developing tooth epithelium. The expression patterns of a Fucci probe clarified the region- and stage-specific cell cycle patterns within the tooth germ, which were in good agreement with the pattern of the volume growth rate estimated from tissue-level deformation analysis. Cellular motility was higher in the regions with higher growth rates, while the mitotic orientation was significantly biased along the direction of tissue elongation in the epithelium. Further, these spatio-temporal patterns of cellular dynamics and tissue-level deformation were highly correlated with that of the activity of cofilin, which is an actin depolymerization factor, suggesting that the coordination of cellular dynamics via actin remodeling plays an important role in tooth epithelial morphogenesis. Our system enhances the understanding of how cellular behaviors are coordinated during ectodermal organogenesis, which cannot be observed from histological analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.