ArticleeNeuro
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
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- Capturing continuous, long timescale behavioral changes in Drosophila melanogaster postural data.PLoS computational biology · 2025Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Review
- GABA has a presynaptic inhibitory effect atmicroPublication biology · 2023Article
- Voltage imaging in the olfactory bulb using transgenic mouse lines expressing the genetically encoded voltage indicator ArcLight.Scientific reports · 2022Article
- Article
- GABAeLife · 2021Article
- Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.The Journal of comparative neurology · 2020Article
- Short term depression, presynaptic inhibition and local neuron diversity play key functional roles in the insect antennal lobe.Journal of computational neuroscience · 2020Article
- NOSA, an Analytical Toolbox for Multicellular Optical Electrophysiology.Frontiers in neuroscience · 2020Article
- Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.Neuron · 2019Article
- Activity-Dependent Remodeling ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Genetically encoded fluorescent voltage indicators: are we there yet?Current opinion in neurobiology · 2018Review
- Genetically expressed voltage sensor ArcLight for imaging large scale cortical activity in the anesthetized and awake mouse.Neurophotonics · 2017Article
- Article
- Odorant Receptor Desensitization in Insects.Journal of experimental neuroscience · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Contrast enhancement mediated by lateral inhibition within the nervous system enhances the detection of salient features of visual and auditory stimuli, such as spatial and temporal edges. However, it remains unclear how mechanisms for temporal contrast enhancement in the olfactory system can enhance the detection of odor plume edges during navigation. To address this question, we delivered to Drosophila melanogaster flies pulses of high odor intensity that induce sustained peripheral responses in olfactory sensory neurons (OSNs). We use optical electrophysiology to directly measure electrical responses in presynaptic terminals and demonstrate that sustained peripheral responses are temporally sharpened by the combined activity of two types of inhibitory GABA receptors to generate contrast-enhanced voltage responses in central OSN axon terminals. Furthermore, we show how these GABA receptors modulate the time course of innate behavioral responses after odor pulse termination, demonstrating an important role for temporal contrast enhancement in odor-guided navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.