ArticleSpringerPlus2016
High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Anti-Cancer Activity ofMarine drugs · 2025Article
- Anticancer Properties of Macroalgae: A Comprehensive Review.Marine drugs · 2025Review
- Pro-Apoptotic Activity of Bioactive Compounds from Seaweeds: Promising Sources for Developing Novel Anticancer Drugs.Marine drugs · 2023Review
- Review
- In vitro cytotoxic potential ofSaudi journal of biological sciences · 2021Article
- The Remarkable Antioxidant and Anti-Inflammatory Potential of the Extracts of the Brown AlgaMarine drugs · 2020Article
- Identification of Asparagopsis armata-associated bacteria and characterization of their bioactive potential.MicrobiologyOpen · 2019Article
- Esophageal cancer research today and tomorrow: Lessons from algae and other perspectives.AIMS genetics · 2018Review
- From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds.Frontiers in pharmacology · 2018Review
- Antimicrobial, antioxidant and anticancer activities ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA.Marine drugs · 2017Article
- Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on anPharmacognosy researchArticle
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Authors and funding
4 authors.
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Abstract
backgroundCancer represents a serious threat for human health with high social and economic impacts worldwide. Therefore, the development of new anticancer drugs is of most importance. The aim of the present study was to evaluate the antitumor potential of twelve algae from Portugal coast on an in vitro model of human hepatocellular carcinoma (HepG-2 cells).
resultsBoth extracts of Asparagopsis armata (1000 µg/ml; 24 h) presented high cytotoxicity with 11.22 ± 2.98 and 1.51 ± 0.38 % of HepG-2 live cells, respectively. Sphaerococcus coronopifolius methanolic and dichloromethane extracts (1000 µg/ml) also generated high reduction on HepG-2 viability (14.04 ± 2.62 and 12.84 ± 3.82 % of HepG-2 live cells, respectively). The most potent anti-proliferative activity was induced by dichloromethane extract (1000 µg/ml; 24 h) of Sphaerococcus coronopifolius, Asparagopsis armata and Plocamium cartilagineum with 99.61 ± 0.27, 98.56 ± 0.81 and 85.13 ± 1.04 % of cell's proliferation reduction, respectively. Sphaerococcus coronopifolius dichloromethane extract exhibited the highest potency both on cytotoxicity and anti-proliferation assays with an IC50 of 14.1 and 32.3 μg/ml, respectively.
conclusionsSphaerococcus coronopifolius is a promising source of new molecules with possible application on cancer therapeutics.
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