Evidence map›Paper›PMID 27588199›Full record

ArticleClinical & translational immunology2016

Prospective studies of infectious mononucleosis in university students.

Jennifer M Grimm, David O Schmeling, Samantha K Dunmire, Jennifer A Knight, Beth D Mullan, Julie A Ed, Richard C Brundage, Kristin A Hogquist, Henry H Balfour

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jennifer M GrimmDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
David O SchmelingDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Samantha K DunmireDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Jennifer A KnightDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Beth D MullanDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Julie A EdDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Richard C BrundageDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota , Minneapolis, MN, USA.
Kristin A HogquistDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN, USA.
Henry H BalfourDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1993 to 2023
$31.1M
NIAID NIH HHS P01 AI035296
6 · The paper itself

Abstract

We performed an intensive prospective study designed to obtain as much data as possible on the incubation and early illness periods of primary Epstein-Barr virus (EBV) infection. Undergraduate students who lacked EBV antibody and oral EBV DNA (EBV-naive) were seen every 2 weeks during their freshman year. Clinical and behavioral data, oral washes and venous blood were obtained. EBV antibodies were quantified by enzyme immunoassay and viral loads by PCR. During a median 8 months of observation, 14/85 subjects experienced primary EBV infections (24 cases/100 person-years). The only significant risk factor for acquisition of EBV infection was deep kissing (P=0.02). Eleven subjects had infectious mononucleosis with a median duration of 21 days. Two subjects were hospitalized. Infections were initially identified in 12 subjects by finding EBV DNA in oral cells before onset of symptoms and in 2 subjects by symptom reporting. EBV DNA and viral capsid antigen (VCA) IgM and gp350 IgG antibodies were present in the blood before onset of illness. To provide a more robust evaluation of primary EBV infection in undergraduate university students, we combined data on risk factors and antibody responses from this and an earlier study that used the exact same clinical and laboratory methods. The observation that the only significant risk factor for acquisition of EBV infection was deep kissing was confirmed. Most importantly, higher amounts of gp350 antibody correlated significantly with a lower severity of infectious mononucleosis (P<0.0001), which strengthens the rationale for a gp350-based prophylactic EBV vaccine.

Identifiers

PMID27588199
PMCPMC5007628
OpenAlexW2510924939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.