ArticleExperimental and therapeutic medicine2016
Effects of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell counts.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Corneal Structural Alterations Under Chronic Hyperglycemia: Biomechanical and Densitometric Insights in Type 2 Diabetes with and Without Retinopathy.Beyoglu eye journal · 2026Article
- Comparative study of corneal endothelial morphology and central corneal thickness in diabetic and non-diabetic patients at tertiary care centre.BMC ophthalmology · 2025Article
- Evaluation of corneal densitometry using Pentacam in patients with type 2 diabetes mellitus: a controlled cross-sectional study.BMC ophthalmology · 2025Article
- Tear proteomics reveals expressed proteins and potential pathways associated with diabetic keratopathy.Eye (London, England) · 2025Article
- Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects.Antioxidants (Basel, Switzerland) · 2024Review
- Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic.International journal of ophthalmology · 2023Article
- Corneal optical density: Structural basis, measurements, influencing factors, and roles in refractive surgery.Frontiers in bioengineering and biotechnology · 2023Review
- Improvement of Corneal Nerve Regeneration in Diabetic Rats Using Wharton's Jelly-Derived Mesenchymal Stem Cells and their Conditioned Medium.International journal of molecular and cellular medicine · 2022Article
- Mechanistic investigations of diabetic ocular surface diseases.Frontiers in endocrinology · 2022Review
- The findings of corneal specular microscopy in patients with type-2 diabetes mellitus.BMC ophthalmology · 2020Article
- Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity.PloS one · 2020Article
- An Update on Corneal Biomechanics and Architecture in Diabetes.Journal of ophthalmology · 2019Review
- Transforming growth factor-β blocks glucose-induced inflammation and apoptosis in corneal epithelial cells.FEBS open bio · 2018Article
- A comparative study of risk factors for corneal infection in diabetic and non-diabetic patients.International journal of ophthalmology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic keratopathy is an ocular complication that occurs with diabetes. In the present study, the effect of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell count was investigated. One hundred and eighty diabetic patients (360 eyes) were enrolled in the study during the period from March, 2012 to March, 2013. The patients were divided into three age groups: <5, 5-10 and >10 years, with 60 patients per group (120 eyes). During the same period, 60 healthy cases (120 eyes) were selected and labeled as the normal control group. The Pentacam was used to measure the corneal optical density, and central corneal thickness. Specular microscopy was used to examine the corneal endothelial cell density. The coefficient of partial correlation was used to control age and correlate the analysis between the corneal optical density, corneal endothelial cell density, and central corneal thickness. The stage of the disease, the medial and intimal corneal optical density and central corneal thickness was analyzed in the diabetes group. The corneal optical density in the diabetes group increased compared with that of the normal control group. The medial and intimal corneal optical density and central corneal thickness were positively correlated with the course of the disease. However, the corneal endothelial cell density was not associated with the course of diabetes. There was a positive association between the medial and intimal corneal optical density and central corneal thickness of the diabetic patients. In conclusion, the results of the present study show that medial and intimal corneal optical density and central corneal thickness were sensitive indicators for early diabetic keratopathy.
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