Evidence map›Paper›PMID 27588044›Full record

ArticleGut pathogens2016

Does antibiotic resistance impair plasma susceptibility of multi-drug resistant clinical isolates of enterococci in vitro?

Matthias Napp, Sebastian von Podewils, Ingo Klare, Hermann Haase, Richard Kasch, Denis Gümbel, Axel Ekkernkamp, Michael Jünger, Georg Daeschlein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Plasma-Activated Water Against Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthias NappDepartment of Surgery, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Sebastian von PodewilsDepartment of Dermatology, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Ingo KlareNational Reference Center for Staphylococci and Enterococci, Robert-Koch-Institute, Wernigerode branch, Burgstraße 37, 38855 Wernigerode, Germany.
Hermann HaaseDepartment of Dermatology, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Richard KaschDepartment of Orthopaedics, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Denis GümbelDepartment of Surgery, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany ; Unfallkrankenhaus Berlin (ukb), Warener Straße 7, 12683 Berlin, Germany.
Axel EkkernkampDepartment of Surgery, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany ; Unfallkrankenhaus Berlin (ukb), Warener Straße 7, 12683 Berlin, Germany.
Michael JüngerDepartment of Dermatology, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Georg DaeschleinDepartment of Dermatology, Ernst Moritz Arndt University, Sauerbruchstrasse, 17475 Greifswald, Germany.
Universität Greifswald · DEUniversitätsmedizin Greifswald · DERobert Koch Institute · DEUnfallkrankenhaus Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCold atmospheric plasma could constitute an alternative against multi-drug resistant pathogens. Susceptibility of enterococci to cold atmospheric plasma was investigated in vitro.

methods39 clinical isolates of enterococci were grouped dependent on the most important resistance patterns and treated on agar using dielectric barrier discharge plasma. These included enterococci with combined vancomycin- and high-level gentamicin resistance, high-level resistance to gentamicin (HLGR) only, vancomycin resistance alone (VRE), and enterococci susceptible to both. Susceptibility to cold atmospheric plasma was evaluated based on the zones of inhibition and examined in terms of the enterococcal group and the "degree" of drug resistance.

resultsCold atmospheric plasma treatment killed all groups. Comparison of VRE and HLGR strains with non-VRE and non-HLGR isolates concerning zones of inhibition revealed that enterococci with special resistance patterns (VRE and HLGR) showed significantly smaller zones of inhibition than the sensitive ones. The mean of all isolates, irrespective of belonging to groups, showed smaller zones of inhibition with increasing "degree" of drug resistance.

conclusionsCold atmospheric plasma treatment killed all isolates of enterococci, but its efficacy depended on the "degree" of drug resistance and on membership in special resistance groups with particular clinical-outbreak importance. However, a possible role of the different genetic lineages, which might be prone to acquiring more or less resistance phenotypes, may also play a role in this context.

Indexed as

Antimicrobial efficacyCold atmospheric plasma (CAP)Dielectric barrier discharge plasma (DBD)Gentamicin-resistant enterococciPlasma medicinePlasma susceptibilityVancomycin-resistant enterococci

Identifiers

PMID27588044
PMCPMC5007836
OpenAlexW2511467629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.